Naltrexone does not block the subjective effects of oral Δ9-tetrahydrocannabinol in humans
Naltrexone does not block the subjective effects of oral Δ9-tetrahydrocannabinol in humans
复制标题
DOI：
10.1016/s0376-8716(99)00127-1
复制
发表时间：
2000-06-01
影响因子：
4.2
通讯作者：
de Wit, H
中科院分区：
文献类型：
--
作者：
Wachtel, SR;de Wit, H
Delta（9）-tetrahydrocannabinol（THC）和阿片类药物有许多共同的作用。此外，实验动物中的一些THC效应可以被阿片拮抗剂阻断或减弱。这表明阿片系统介导或调节一些THC效应。为了确定阿片系统是否介导人类THC效应，在14名大麻使用者中检查了阿片拮抗剂纳洛酮对THC主观反应的影响。受试者参与双盲交叉设计，其中每个受试者接受纳洛酮（0或50 mg）和THC（0、7.5或15 mg）的所有组合。THC增加心率和自我报告的药物作用，如欣快和大麻样作用，并降低精神表现。纳洛酮增加了心率，降低了自我报告的活力和饥饿感，但没有改变THC的任何影响。这些结果表明，THC对人类的主观，生理和行为影响不是通过阿片系统介导的。(C)2000爱思唯尔科学爱尔兰有限公司保留所有权利。
Delta(9)-tetrahydrocannabinol (THC) and opioids have many common effects. Tn addition, some THC effects in laboratory animals can be blocked or attenuated by opioid antagonists. This suggests that opioid systems mediate or modulate some THC effects. To determine whether opioid systems mediate THC effects in humans, the effects of the opioid antagonist naltrexone on subjective responses to THC were examined in 14 marijuana users. Subjects participated in a double-blinded, cross-over design in which each subject received all combinations of naltrexone (0 or 50 mg) and THC (0, 7.5, or 15 mg). THC increased heart rate and self-reported drug effects, such as euphoria and marijuana-like effects, and decreased psychomotor performance. Naltrexone increased heart rate and decreased self-reported measures of vigor and hunger but did not alter any of the effects of THC. These results suggest that the subjective, physiological, and behavioral effects of THC in humans are not mediated through opioid systems. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.