Resting energy expenditure in children with neonatal chronic lung disease and obstruction of the airways.
Resting energy expenditure in children with neonatal chronic lung disease and obstruction of the airways.
复制标题
患有新生儿慢性肺病和气道阻塞的儿童的静息能量消耗。
DOI：
--
复制
发表时间：
2007
影响因子：
3.6
通讯作者：
F. Gottrand
中科院分区：
文献类型：
--
作者：
L. Bott;L. Béghin;R. Hankard;V. Pierrat;E. Gondon;F. Gottrand
有支气管-肺发育不良(BPD)病史的儿童通常会出现生长衰竭和肺部后遗症。本研究的主要目的是测试肺梗阻对BPD患者静息能量消耗(REE)和营养状况的影响。BPD患儿71例(男34例，女37例)，对照组30例(男20例，女10例)，年龄4~8岁。人体成分用生物阻抗法测量；稀土元素用间接量热法测量。用肖菲尔德方程计算了稀土元素的预测值。将患有BPD的儿童分为三组：无呼吸道阻塞儿童、中度呼吸道阻塞儿童和重度阻塞儿童。与对照组相比，患有BPD的儿童明显更小、更瘦。在患有呼吸道阻塞的BPD儿童中，观察到身体成分的改变(脂肪质量减少)。BPD儿童的REE与对照组相比显著降低，但当调整体重和无脂肪质量时，无论肺状态如何，都没有观察到显著差异。BPD儿童的呼吸道阻塞似乎与REE增加无关。此外，REE的改变不能解释BPD儿童后期仍可观察到的营养状态的改变。这支持了一种假设，即BPD儿童后期的身体成分和肺功能是源于新生儿期的固定后遗症。
Children with history of broncho-pulmonary dysplasia (BPD) often suffer from growth failure and lung sequelae. The main objective of this study was to test the role of pulmonary obstruction on resting energy expenditure (REE) and nutritional status in BPD. Seventy-one children with BPD (34 boys and 37 girls) and 30 controls (20 boys and 10 girls) aged 4-8 years were enrolled. Body composition was assessed by bio-impedancemetry measurements; REE was measured by indirect calorimetry. Predicted REE was calculated using the Schofield equation. The population of children with BPD was divided into three groups: children without obstruction of the airways, children with moderate obstruction of the airways, and children with severe obstruction. Children with BPD were significantly smaller and leaner than controls. Altered body composition (reduction of fat mass) was observed in BPD children that suffered from airway obstruction. REE was significantly lower in children with BPD compared to controls, but when adjusted for weight and fat-free mass no significant difference was observed irrespective of pulmonary status. Airway obstruction in children with BPD does not appear to be associated with an increased REE. Moreover altered REE could not explain the altered nutritional status that is still observed in BPD in later childhood. This supports the hypothesis that body composition and pulmonary function in BPD in later childhood are fixed sequelae originating from the neonatal period.