Metallic Glass Nanofibers in Future Hydrogel-based Scaffolds
Metallic Glass Nanofibers in Future Hydrogel-based Scaffolds
复制标题
未来水凝胶支架中的金属玻璃纳米纤维
DOI：
10.1109/embc.2014.6944816
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
and Ali Khademhosseini
中科院分区：
文献类型：
--
作者：
Ramin Banan Sadeghian;Samad Ahadian;Shin Yaginuma;Javier Ramón-Azcón;Xiaobin Liang;Ken Nakajima;Hitoshi Shiku;Tomokazu Matsue;Koji S. Nakayama;and Ali Khademhosseini
导电增强水凝胶作为三维支架在组织工程中有着广泛的应用。我们报道了含有钯基金属玻璃纳米纤维（MGNF）的甲基丙烯酸明胶（GelMA）水凝胶的电学和力学特性。此外，我们还发现纤维具有生物相容性，特别是种植在杂交水凝胶中的C2C12成肌细胞，倾向于附着在纤维上并沿着纤维伸长。这项工作中的MGNFs是通过气体雾化产生的。将拉威尔纤维包埋在两种不同浓度（0.5和1.0 mg/ml）的GelMA预聚物中，然后在紫外光下固化，形成杂交水凝胶。杂化水凝胶的电导率与纤维浓度成正比。
Electrically conductive reinforced hydrogels offer a wide range of applications as three-dimensional scaffolds in tissue engineering. We report electrical and mechanical characterization of methacrylated gelatin (GelMA) hydrogel, containing palladium-based metallic glass nanofibers (MGNF). Also we show that the fibers are biocompatible and C2C12 myoblasts in particular, planted into the hybrid hydrogel, tend to attach to and elongate along the fibers. The MGNFs in this work were created by gas atomization. Ravel of fibers were embedded in the GelMA prepolymer in two different concentrations (0.5 and 1.0 mg/ml), and then the ensemble was cured under UV light, forming the hybrid hydrogel. The conductivity of the hybrid hydrogel was proportional to the fiber concentration.