Repeated ozone exposures enhance bronchial allergen responses in subjects with rhinitis or asthma
Repeated ozone exposures enhance bronchial allergen responses in subjects with rhinitis or asthma
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DOI：
10.1046/j.1365-2222.2002.01358.x
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发表时间：
2002-05-01
影响因子：
6.1
通讯作者：
Jörres, RA
中科院分区：
文献类型：
--
作者：
Holz, O;Mücke, M;Jörres, RA
背景单次暴露于> 200 p.p.b.目的比较单次和多次臭氧暴露对过敏原早期和晚期肺功能的影响。250 p.p.b.臭氧，以及反复暴露于125 p.p.b.臭氧连续四天。结果鼻炎患者暴露于250或4 × 125 p.p.b.后，FEV 1的平均早期反应和大于或等于20%的减少数显著高于对照组（P < 0. 05）。臭氧与过滤空气相比。此外，大多数大于或等于15%的FEV 1晚期反应发生在暴露于4 x 125 p.p.b.后，以及对痰参数的最强影响。两组中嗜酸性粒细胞数量的增加具有统计学显著性。关于淋巴细胞的数量和肥大细胞类胰蛋白酶，组胺或LDH的浓度，显着性，但是，只达到了在哮喘group.Conclusion我们的数据表明，反复暴露于臭氧，在一个峰值的环境空气水平，可以提高功能和炎症反应吸入过敏原的受试者与预先存在的过敏性气道疾病，这些影响可能达到临床相关的幅度。
Background Single exposures to > 200 p.p.b. of ozone are capable of enhancing the early-phase lung function response to allergen.Objective The aim of the present study was to compare the effect of single vs. repeated exposures to ozone on early and late-phase allergen responses.Methods Eleven subjects with allergic asthma and 22 subjects with allergic rhinitis underwent single exposures to filtered air, 125 p.p.b. and 250 p.p.b. ozone, as well as repeated exposures to 125 p.p.b. ozone on four consecutive days. Twenty hours after the (final) exposure, subjects inhaled a single dose of allergen and a sputum induction was performed 6-7 h later.Results In the subjects with rhinitis, the mean early-phase response of FEV1 and the number of greater than or equal to 20% reductions were significantly greater after exposure to 250 or 4 x 125 p.p.b. ozone compared with filtered air. In addition, most of the greater than or equal to 15% late-phase responses in FEV1 occurred after exposure to 4 x 125 p.p.b., as well as the strongest effects on sputum parameters. The rise in the number of eosinophils was statistically significant in both groups. Regarding the number of lymphocytes and the concentrations of mast cell tryptase, histamine or LDH, significance was, however, only reached in the asthma group.Conclusion Our data suggest that repeated exposure to ozone, at a peak ambient air level, can enhance both functional and inflammatory responses to inhaled allergen in subjects with pre-existing allergic airway diseases, and that these effects might reach a clinically relevant magnitude.