Influence of Adjuvant Radiotherapy Timing on Survival Outcomes in High-Risk Patients Receiving Neoadjuvant Treatments.
Influence of Adjuvant Radiotherapy Timing on Survival Outcomes in High-Risk Patients Receiving Neoadjuvant Treatments.
复制标题
辅助放射治疗时间对接受新辅助治疗的高危患者的生存结果的影响。
DOI：
10.3389/fonc.2022.905223
复制
发表时间：
2022
影响因子：
4.7
通讯作者：
Chen, Jia-Yi
中科院分区：
文献类型：
--
作者：
Cao, Lu;Xu, Cheng;Wang, Meng-Di;Qi, Wei-Xiang;Cai, Gang;Cai, Rong;Wang, Shu-Bei;Ou, Dan;Li, Min;Shen, Kun-Wei;Chen, Jia-Yi
关键词：
确定乳腺癌（BC）患者接受新辅助治疗（NATs）的放射治疗时间（TTR）与生存结局之间的关系。回顾性分析2009年至2016年连续接受NAT和辅助放疗（RT）的非转移性BC患者。采用限制三次样条的多变量Cox模型（RCSs）来确定TTR与生存结局之间的全景关系。采用多变量分析控制TTR组间的混杂因素。共纳入315例患者。RCS模型显示TTR与生存结果之间存在非线性关系。在TTR 12周时观察到无远处转移生存（DMFS）和无复发生存（RFS）的最低风险，在10周时观察到bc特异性生存（BCSS）的最低风险。TTR相应转化为≤10周、11-20周和bb0 - 20周的分类变量。多变量分析显示，TTR≤10周是DMFS （HR = 2.294, 95% CI 1.079 ~ 4.881）和RFS （HR = 2.126, 95% CI 1.038 ~ 4.356）较TTR 10 ~ 20周恶化的独立预后因素，而TTR 10 ~ 20周与TTR 10 ~ 20周DMFS、RFS和BCSS差异无统计学意义。在接受NAT治疗的患者中，术后TTR与生存结果之间存在非线性关系。术后早期开始RT似乎与更好的治疗结果无关。临床可采用相对灵活的推荐TTR。
To determine the relationship between time to radiotherapy (TTR) and survival outcomes in breast cancer (BC) patients treated with neoadjuvant treatments (NATs). Continuous non-metastatic BC patients receiving NAT and adjuvant radiotherapy (RT) from 2009 to 2016 were retrospectively reviewed. A multivariable Cox model with restricted cubic splines (RCSs) was used to determine the panoramic relationship between TTR and survival outcomes. Multivariable analysis was used to control for confounding factors between the groups of TTR. A total of 315 patients were included. The RCS modeling demonstrated a non-linear relationship between TTR and survival outcomes. The lowest risk for distant metastasis-free survival (DMFS) and recurrence-free survival (RFS) was observed at the TTR of 12 weeks, and the lowest risk of BC-specific survival (BCSS) at 10 weeks. TTR was accordingly transformed into categorical variables as ≤10, 11–20, and >20 weeks. Multivariable analysis revealed that the TTR of ≤10 weeks was an independent prognostic factor for worse DMFS (HR = 2.294, 95% CI 1.079–4.881) and RFS (HR = 2.126, 95% CI 1.038–4.356) compared with the TTR of 10–20 weeks, while the is no difference in DMFS, RFS, and BCSS between TTR >20 weeks and TTR of 10–20 weeks. There exists a non-linear relationship between TTR after surgery and survival outcomes in patients treated with NAT. Early initiation of RT following surgery does not seem to be associated with a better therapeutic outcome. A relatively flexible recommendation of TTR could be adopted in clinical practice.
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影响因子：
8.4
作者：
Eisenhauer, E. A.;Therasse, P.;Verweij, J.
通讯作者：
Verweij, J.
乳房切除术后直线加速器 IMRT 胸壁和区域淋巴结照射：剂量测定数据和急性毒性
DOI：
10.1186/1748-717x-8-81
发表时间：
2013-04-08
期刊：
Radiation oncology (London, England)
影响因子：
--
作者：
Ma J;Li J;Xie J;Chen J;Zhu C;Cai G;Zhang Z;Guo X;Chen J
通讯作者：
Chen J
影响因子：
3.9
作者：
Sun, Zhifei;Adam, Mohamed A.;Migaly, John
通讯作者：
Migaly, John
影响因子：
28.4
作者：
Salazar, Michelle C.;Rosen, Joshua E.;Boffa, Daniel J.
通讯作者：
Boffa, Daniel J.
影响因子：
3.9
作者：
Ogston, KN;Miller, ID;Heys, SD
通讯作者：
Heys, SD