Disturbed functional connectivity within brain networks subserving domain-specific subcomponents of working memory in schizophrenia: Relation to performance and clinical symptoms
Disturbed functional connectivity within brain networks subserving domain-specific subcomponents of working memory in schizophrenia: Relation to performance and clinical symptoms
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DOI：
10.1016/j.jpsychires.2009.09.003
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发表时间：
2010-04-01
影响因子：
4.8
通讯作者：
Gruber, Oliver
中科院分区：
文献类型：
--
作者：
Henseler, Ilona;Falkai, Peter;Gruber, Oliver
区域间功能连接障碍被假设为精神分裂症的一个有希望的标志。然而，工作记忆（WM）损伤、功能连接紊乱和精神分裂症的特征性症状之间的关系仍然难以捉摸。方法：利用功能磁共振成像（fMRI）研究了精神分裂症患者和对照组在执行不同任务时选择性参与工作记忆子成分过程的功能连接模式。结果：与对照组相比，在非发音性语音信息维持过程中，患者前额叶皮层与顶叶内皮层和海马的连通性降低，腹外侧和背外侧前额叶皮层之间存在异常的负相互作用。在视觉空间信息维持过程中，患者表现出顶叶上皮层和枕叶上皮层区域之间的连通性降低，而额叶视野与视觉加工区域的正连通性增强。讨论：我们的研究结果表明，在精神分裂症中支持工作记忆功能的网络中存在复杂的失调，其表现为积极相互作用减少和异常的消极相互作用。连接强度和WM表现之间的相关性表明，这些失调可能是精神分裂症中WM缺陷的神经功能相关。前额叶-海马和顶叶-枕叶连通性的改变进一步被发现与较高的阳性症状相关，这为妄想和紊乱症状的发展提供了可能的解释。结论：本研究结果有助于更好地理解脑同步活动模式改变与精神分裂症认知和临床症状之间的关系。2009爱思唯尔有限公司版权所有。
Introduction: Disturbed interregional functional connectivity has been hypothesized to be a promising marker of schizophrenia. The relationship between working memory (WM) impairment, disturbed functional connectivity, and the characteristic symptoms of schizophrenia, however, remains elusive.Methods: We used functional MRI (fMRI) to investigate in patients with schizophrenia and matched controls the patterns of functional connectivity during the performance of different tasks selectively engaging subcomponent processes of working memory.Results: Compared with controls, patients showed reduced connectivity of the prefrontal cortex with the intraparietal cortex and the hippocampus and abnormal negative interactions between the ventrolateral and dorsolateral prefrontal cortex during the non-articulatory maintenance of phonological information. During the maintenance of visuospatial information, patients presented reduced connectivity between regions in the superior parietal and occipital cortex, as well as enhanced positive connectivity of the frontal eye field with visual processing areas.Discussion: Our findings suggest complex dysregulations within the networks supporting working memory functions in schizophrenia, which manifest as decreased positive and abnormal negative interactions. Correlations between the connection strength and WM performance suggest that these dysregulations may be neurofunctional correlates of the WM deficits seen in schizophrenia. Altered prefronto-hippocampal and parieto-occipital connectivity was further found to be associated with higher positive symptoms, providing a possible explanation for the development of delusions and disorganization symptoms.Conclusion: The present findings can help to better understand the relationship between altered patterns of synchronized brain activity and the cognitive and clinical symptoms of schizophrenia. (C) 2009 Elsevier Ltd. All rights reserved.