Spectral analysis highlight developmental EEG changes in preterm infants without overt brain damage
Spectral analysis highlight developmental EEG changes in preterm infants without overt brain damage
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DOI：
10.1016/j.neulet.2017.04.021
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发表时间：
2017-05-10
影响因子：
2.5
通讯作者：
Bisiacchi, Patrizia S.
中科院分区：
文献类型：
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作者：
Suppiej, Agnese;Cainelli, Elisa;Bisiacchi, Patrizia S.
在没有明显脑损伤的情况下，极早产儿的神经学结局的早期标志物很少。本研究的目的是比较频谱EEG值的婴儿出生在极低胎龄（ELGA），但已达到近足月的婴儿。我们的目的还在于评估频谱EEG特征是否与神经学结果相关。ELGA组由12名出生于23 + 2周和27 + 6周之间的新生儿组成;对照组由9名出生于34-35 + 2周的婴儿组成，在出生后第一周内进行测试。所有新生儿在受孕后35周进行多通道EEG记录。在记录时，所有受试者均无明显的神经系统异常或风险因素。将EEG数据转换到频域，并划分为delta（0.5-4 Hz）、theta（5-7 Hz）、alpha（8-13 Hz）、beta（14-20 Hz）频带;计算相对EEG功率值。ELGA组与对照组比较采用混合方差分析。在1岁时用Griffiths量表评价结局。ELGA组δ频段的总相对功率显著高于对照组，而其余频段的总相对功率则显著低于对照组。较高的δ值和较低的α和β谱功率值与不良结局相关。我们提供的初步结果表明，早在35周后的概念，出生极早产儿未能开发的EEG频谱活动的年龄特异性模式，在没有神经新生儿的风险。(C)2017爱思唯尔B. V.保留所有权利。
Early markers of neurological outcome in the absence of overt brain damage are scarce in extreme prematurity. The aim of this study was to compare spectral EEG values of infants born near term with those of infants born at extremely low gestational age (ELGA) but having attained near term age. We aimed also to evaluate whether spectral EEG features were related with neurological outcome. The ELGA group consisted of 12 neonates born between 23 + 2 and 27 + 6 weeks; the control group consisted of nine infants born 34-35 +2 weeks, tested within the first week of life. All neonates underwent multichannel EEG recordings at 35 weeks post-conception. None of the subjects had apparent neurological abnormalities or risk factors at the time of recording. EEG data were transformed into the frequency domain and divided into delta (0.5-4 Hz), theta (5-7 Hz), alpha (8-13 Hz), beta (14-20 Hz) frequency bands; relative EEG power values were calculated. ELGA group was compared with the control group using a mixed analysis of variance. Outcome was evaluated at one year of age by Griffiths' scales. A principal effect of frequency and an interaction effect of frequency * group was found. The total relative power of the delta band was significantly higher in ELGA than in control group, whereas in the remaining frequency bands total relative power was lower in ELGA than in control group. Higher values of delta and lower values of alpha and beta spectral power correlated with poor outcome. We provide preliminary results suggesting that, as early as 35 weeks post conception, infants born extremely preterm fail to develop the age specific pattern of EEG spectral activity, in the absence of neurological neonatal risk. (C) 2017 Elsevier B.V. All rights reserved.