FDG-PET. A possible prognostic factor in head and neck cancer.
FDG-PET. A possible prognostic factor in head and neck cancer.
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DOI：
10.1038/sj.bjc.6600114
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发表时间：
2002-02-12
影响因子：
8.8
通讯作者：
McGurk, M
中科院分区：
文献类型：
--
作者：
Halfpenny, W;Hain, S F;Biassoni, L;Maisey, M N;Sherman, J A;McGurk, M
先前的研究表明，根据正电子发射断层扫描的标准化摄取值，头颈癌患者对18f -氟-2-脱氧葡萄糖的高摄取与生存率低有关。本研究的目的是确认两者之间的联系，并确定高标准化摄取值是否具有预后意义。73例连续的新诊断的头颈部鳞状细胞癌患者在治疗前接受了正电子发射断层扫描。分析年龄、性别、运动状态、肿瘤分级、分期、最大肿瘤直径和标准化摄取值与生存的可能关系。所有原发性肿瘤的标准化摄取值中位数为7.16（90%范围为2.30至18.60）。在单因素生存分析中，累积生存率随着分期、肿瘤直径和标准化摄取值的增加而降低。标准摄取值为10作为高摄取和低摄取肿瘤的分界点。当这两组进行比较时，标准化摄取值bbb10预测预后明显较差（P=0.003）。多变量分析表明，标准化摄取值bbb10提供了与肿瘤分期和直径无关的预后信息（P=0.002）。我们得出结论，在正电子发射断层扫描上，高FDG摄取（标准摄取值bbb10）是原发性头颈部鳞状细胞癌预后不良的重要标志。标准化摄取值可能有助于区分那些具有更强侵袭性生物学性质的肿瘤，从而确定需要强化治疗方案的患者，包括高分割放疗和/或化疗。英国癌症杂志（2002）86,512-516。DOI: 10.1038/sj/bjc/6600114 www.bjcancer.com©2002英国癌症研究中心
Previous studies have shown that high uptake of 18F-fluoro-2-deoxy-glucose in head and neck cancer, as determined by the standardized uptake value on positron emission tomography scan, was associated with poor survival. The aim of this study was to confirm the association and to establish whether a high standardized uptake value had prognostic significance. Seventy-three consecutive patients with newly diagnosed squamous cell carcinoma of the head and neck underwent a positron emission tomography study before treatment. Age, gender, performance status tumour grade, stage, maximal tumour diameter and standardized uptake value were analyzed for their possible association with survival. The median standardized uptake value for all primary tumours was 7.16 (90% range 2.30 to 18.60). In univariate survival analysis the cumulative survival was decreased as the stage, tumour diameter and standardized uptake value increased. An standardized uptake value of 10 was taken as a cut-off for high and low uptake tumours. When these two groups were compared, an standardized uptake value >10 predicted for significantly worse outcome (P=0.003). Multivariate analysis demonstrated that an standardized uptake value >10 provided prognostic information independent of the tumour stage and diameter (P=0.002). We conclude that high FDG uptake (standardized uptake value>10) on positron emission tomography is an important marker for poor outcome in primary squamous cell carcinoma of the head and neck. Standardized uptake value may be useful in distinguishing those tumours with a more aggressive biological nature and hence identifying patients that require intensive treatment protocols including hyperfractionated radiotherapy and/or chemotherapy. British Journal of Cancer (2002) 86, 512–516. DOI: 10.1038/sj/bjc/6600114 www.bjcancer.com © 2002 Cancer Research UK