Increased incidence of brain metastases in cutaneous head and neck melanoma
Increased incidence of brain metastases in cutaneous head and neck melanoma
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DOI：
10.1097/00008390-200504000-00006
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发表时间：
2005-04-01
影响因子：
2.2
通讯作者：
Hoekstra, HJ
中科院分区：
文献类型：
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作者：
Daryanani, D;Plukker, JT;Hoekstra, HJ
皮肤黑色素瘤的发病率正在增加，并且这些黑色素瘤的10-20%位于头颈部区域。分析了头颈部黑色素瘤脑转移的发生率、危险因素和预后。在1965-2000年期间，324例患者[12例女性（47%），172例男性（53%）]接受了头颈部皮肤黑色素瘤治疗。根据2002年美国癌症联合委员会（AJCC）黑色素瘤分期系统对患者进行分期。进行了匹配对照分析，以确定脑转移发生的危险因素。采用交叉表法、卡方检验和logistic回归分析方法进行分析。26例（8%）头颈部患者发生脑转移，而肢体/躯干患者发生脑转移的比例为5.2%（可信区间为0.058-0.108; P
The incidence of cutaneous melanoma is increasing, and 10-20% of these melanomas are located in the head and neck region. The incidence of brain metastases, risk factors and outcome were analysed for melanomas originating in the head and neck region. During the period 1965-2000, 324 patients [12 females (47%), 172 males (53%)] were treated for cutaneous melanoma of the head and neck. The patients were staged according to the 2002 American Joint Committee on Cancer (AJCC) melanoma staging system. A matched control analysis was performed in order to identify the risk factors for the occurrence of brain metastases. The analysis was performed using cross-tabulations, chi-squared test and the logistic regression method. Twenty six (8%) head and neck patients, compared with 5.2% of extremity/truncal patients, developed brain metastases (confidence interval, 0.058-0.108; P