Rehabilitation Program After Mesenchymal Stromal Cell Transplantation Augmented by Vascularized Bone Grafts for Idiopathic Osteonecrosis of the Femoral Head: A Preliminary Study
Rehabilitation Program After Mesenchymal Stromal Cell Transplantation Augmented by Vascularized Bone Grafts for Idiopathic Osteonecrosis of the Femoral Head: A Preliminary Study
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DOI：
10.1016/j.apmr.2014.09.040
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发表时间：
2015-03-01
影响因子：
4.3
通讯作者：
Toguchida, Junya
中科院分区：
文献类型：
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作者：
Aoyama, Tomoki;Fujita, Yasuko;Toguchida, Junya
目的：为了确定间充质基质细胞（MSC）移植后血管化骨移植增强的12周康复计划的可行性和安全性，特发性股骨头坏死（ION）。设计：前瞻性病例系列。设置：大学临床研究实验室。参与者：接受MSC移植血管化骨移植增强的ION参与者（N=10）。干预：为期12周的运动计划，包括活动范围（ROM）练习、肌肉强化练习和有氧训练。主要结果测量：活动范围、肌肉力量、计时起身和行走测试和医疗结果研究36项简短健康调查（SF-36）在手术前以及手术后6个月和12个月再次收集。结果：所有参与者都完成了为期12周的计划。治疗后6个月外旋活动度、伸肌和外展肌肌力较治疗前明显改善（P
Objective: To determine the feasibility and safety of implementing a 12-week rehabilitation program after mesenchymal stromal cell (MSC) transplantation augmented by vascularized bone grafting for idiopathic osteonecrosis (ION) of the femoral head.Design: A prospective case series.Setting: University clinical research laboratory.Participants: Participants (N=10) with ION who received MSC transplantation augmented by vascularized bone grafting.Intervention: A 12-week exercise program, which included range-of-motion (ROM) exercises, muscle-strengthening exercises, and aerobic training.Main Outcome Measures: Measures of ROM, muscle strength, Timed Up and Go test, and Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) were collected before surgery and again at 6 and 12 months after surgery.Results: All participants completed the 12-week program. External rotation ROM as well as extensor and abductor muscle strength significantly improved 6 months after treatment compared with that before treatment (P