Carotid Artery Calcification Is Associated with Deep Cerebral Microbleeds
Carotid Artery Calcification Is Associated with Deep Cerebral Microbleeds
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DOI：
10.1159/000358513
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发表时间：
2014-01-01
影响因子：
2.4
通讯作者：
Ha, Sam-Yeol
中科院分区：
文献类型：
--
作者：
Chung, Pil-Wook;Park, Kwang-Yeol;Ha, Sam-Yeol
背景/目的：本研究的目的是确定动脉钙化与脑微出血（CMB）分布之间的关系。方法：我们对834例急性缺血性卒中或短暂性缺血性发作患者进行了CT血管造影和敏感性加权成像。结果：颈内动脉钙化660例（79.1%），颈内动脉钙化335例（40.2%）。ICA钙化与任何部位的CMB独立相关（优势比OR为2.86,95% CI为2.01-4.08,p < 0.0001）。钙化与深部CMB之间的相关性更强（OR 3.51, 95% CI 2.39-5.14, p < 0.0001）。然而，ICA钙化与CMB在严格意义上的大叶区无关。结论：ICA钙化是深部CMB的独立危险因素，而不是严格意义上的大叶性CMB。我们的发现可能有助于阐明脑血管病的发病机制。(C) 2014 S. Karger AG，巴塞尔
Background/Aims: The aim of the present study was to determine the association between arterial calcification and cerebral microbleeds (CMB) relative to their distribution. Methods: We identified 834 consecutive patients with acute ischemic stroke or transient ischemic attack who underwent CT angiography and susceptibility-weighted imaging. Results: Internal carotid artery (ICA) calcification and CMB were found in 660 patients (79.1%) and 335 patients (40.2%), respectively. ICA calcification was independently associated with CMB of any location (odds ratio, OR, 2.86, 95% CI 2.01-4.08, p < 0.0001). The association between calcification and deep CMB was stronger (OR 3.51, 95% CI 2.39-5.14, p < 0.0001). However, ICA calcification was not associated with CMB in a strictly lobar area. Conclusion: ICA calcification is an independent risk factor for deep CMB but not for a strictly lobar CMB. Our findings might contribute to the elucidation of the pathogenesis of cerebral small vessel disease. (C) 2014 S. Karger AG, Basel