Increased pyrethroid resistance in malaria vectors and decreased bed net effectiveness, Burkina Faso.
Increased pyrethroid resistance in malaria vectors and decreased bed net effectiveness, Burkina Faso.
复制标题
DOI：
10.3201/eid2010.140619
复制
发表时间：
2014-10
影响因子：
11.8
通讯作者：
Ranson H
中科院分区：
文献类型：
--
作者：
Toé KH;Jones CM;N'Fale S;Ismail HM;Dabiré RK;Ranson H
这种新的耐药性将对疟疾控制产生严重影响。疟疾的控制依赖于杀虫剂。在整个非洲，疟疾病媒中杀虫剂耐药性流行率的增加是有据可查的。然而，很少有人尝试量化这种阻力的强度，并将其与控制工具的有效性联系起来。通过定量生物测定，我们发现在布基纳法索，冈比亚按蚊对拟除虫菊酯的抗性近年来强度有所增加，现在已经超过1000倍。在实验室分析中，这种程度的抗药性使得用于浸渍蚊帐的杀虫剂无效。因此，长期驱虫蚊帐运动所提供的个人和社区保护水平可能会降低。需要标准化的方法来量化疟疾病媒的耐药性水平，并将这些水平与病媒控制方法的失败联系起来。
This new resistance will have serious effects on malaria control. Malaria control is dependent on insecticides. Increases in prevalence of insecticide resistance in malaria vectors across Africa are well-documented. However, few attempts have been made to quantify the strength of this resistance and link it to the effectiveness of control tools. Using quantitative bioassays, we show that in Burkina Faso pyrethroid resistance in Anopheles gambiae mosquitoes has increased in intensity in recent years and now exceeds 1,000-fold. In laboratory assays, this level of resistance renders insecticides used to impregnate bed nets ineffective. Thus, the level of personal and community protection afforded by long-lasting insecticide-treated net campaigns will probably be reduced. Standardized methods are needed to quantify resistance levels in malaria vectors and link these levels to failure of vector control methods.