Research progress on rheumatoid arthritis-associated depression.
Research progress on rheumatoid arthritis-associated depression.
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DOI：
10.3389/fnbeh.2022.992223
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发表时间：
2022
影响因子：
3
通讯作者：
中科院分区：
文献类型：
--
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抑郁症是一种独立的情绪障碍，也是类风湿性关节炎（RA）最常见的合并症之一。越来越多的证据表明，RA和抑郁之间存在双向调节，导致RA、抑郁、不良预后和疾病负担的恶性循环。与 RA 相关的抑郁症患病率不断上升，需要重新审视它们之间的关系。在这里，我们概述了 RA 相关抑郁症的病因和病理机制，以及生物制剂治疗的最新进展，这将有助于开发新的有效的预防和治疗策略。
Depression is an independent mood disorder and one of the most common comorbidities of rheumatoid arthritis (RA). Growing evidence suggests that there is two-way regulation between RA and depression, resulting in a vicious cycle of RA, depression, poor outcomes, and disease burden. The rising prevalence of RA-associated depression warrants a re-examination of the relationships between them. Here we provide an overview of the etiology and pathological mechanisms of RA-associated depression, and recent advances in treatment with biologics, which will facilitate the development of new and effective prevention and treatment strategies.