Extracorporeal life support - The University of Michigan experience
Extracorporeal life support - The University of Michigan experience
复制标题
DOI：
10.1001/jama.283.7.904
复制
发表时间：
2000-02-16
影响因子：
120.7
通讯作者：
Hirschl, RB
中科院分区：
文献类型：
--
作者：
Bartlett, RH;Roloff, DW;Hirschl, RB
密歇根大学在1980年至1998年期间对1000名连续患者进行体外生命支持(ECLS)的经历是世界上最大的一次单一机构的经验。在这些患者中，呼吸衰竭的垂死患者的出院存活率为88%(586名新生儿)、70%(132名儿童)和56%(146名成人)。在105名儿童和31名成人中，心力衰竭患者的存活率分别为48%和33%。本文描述了密歇根大学ECLS患者的整体经验，ECLS从实验室实验到临床应用的进展，该技术扩展到其他中心，以及当前的ECLS技术和结果。尽管这一领域的临床研究面临挑战，但我们和其他人的经验表明，ECLS在各种临床环境下拯救了急性心肺衰竭患者的生命。
The University of Michigan experience with extracorporeal life support (ECLS) in 1000 consecutive patients between 1980 and 1998 is the largest series at one institution in the world. Among this patient population, survival to hospital discharge in moribund patients with respiratory failure was 88% in 586 neonates, 70% in 132 children, and 56% in 146 adults. Survival in moribund patients with cardiac failure was 48% in 105 children and 33% in 31 adults. This article describes the University of Michigan's overall ECLS patient experience, the progression of ECLS from laboratory experiments to clinical application at the bedside, the expansion of the technology to other centers, and current ECLS technology and outcomes. Despite the challenges faced in clinical research in this field, our experience and that of others has shown that ECLS saves lives of patients with acute cardiac or pulmonary failure in a variety of clinical settings.