Differences in solute removal by two high-flux membranes of nominally similar synthetic polymers.
Differences in solute removal by two high-flux membranes of nominally similar synthetic polymers.
复制标题
名义上相似的合成聚合物的两种高通量膜去除溶质的差异。
DOI：
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发表时间：
2008
影响因子：
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通讯作者：
R. Ward
中科院分区：
文献类型：
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作者：
R. Ouseph;C. Hutchison;R. Ward
背景
由名义上相似的聚合物制成的膜在化学组成、形态和几何形状上可能明显不同。为了检查这些因素对透析器性能的相对重要性，测定了含有不同组成和形态的“聚砜”膜（有和无纤维波动）的透析器对小型和大型尿毒症毒素的清除。
方法
在随机交叉研究中测定了尿素、磷、β 2-微球蛋白、瘦素、血管生成素、补体因子D和免疫球蛋白κ轻链的总清除率和瞬时清除率。根据透析前后血浆浓度变化和透析液中回收的溶质总量评估总溶质清除。将膜处的溶质捕获确定为从血浆水中损失的溶质与透析液中回收的溶质之间的差异。
结果
尿素和磷的总去除率与膜的组成和结构无关。两种膜的大分子清除率显著不同，特别是β 2-微球蛋白。在膜上捕获作为β 2-微球蛋白清除机制的重要性在两种膜之间也存在显著差异，捕获对于β 2-微球蛋白清除最大的膜不太重要。随着分子尺寸的增加，截留在膜上的溶质去除的贡献增加，两个膜之间的差异减小。
结论
由名义上相似的聚合物制成的高通量膜在去除低分子量蛋白质尿毒症毒素的能力上可能存在显著差异。
BACKGROUND
Membranes fabricated from nominally similar polymers may be markedly different in chemical composition, morphology and geometry. To examine the relative importance of these factors to dialyzer performance, the removal of small and large uraemic toxins was determined for dialyzers containing 'polysulfone' membranes of different composition and morphology, with and without fibre undulations.
METHODS
Total removal and instantaneous clearances of urea, phosphorus, beta(2)-microglobulin, leptin, angiogenin, complement factor D and immunoglobulin kappa light chain were determined in randomized cross-over studies. Total solute removal was assessed from the pre- to post-dialysis change in plasma concentration and the total amount of solute recovered in the dialysate. Trapping of solute at the membrane was determined as the difference between solute lost from plasma water and solute recovered in the dialysate.
RESULTS
Total removal of urea and phosphorus was independent of the membrane composition and structure. Large molecule removal differed significantly between the two membranes, particularly for beta(2)-microglobulin. The importance of trapping at the membrane as a mechanism of beta(2)-microglobulin removal also differed significantly between the two membranes, with trapping being less important for the membrane with the greatest beta(2)-microglobulin removal. As molecular size increased, the contribution of trapping at the membrane to solute removal increased and the difference between the two membranes decreased.
CONCLUSIONS
High-flux membranes fabricated from nominally similar polymers may differ significantly in their ability to remove low molecular weight protein uraemic toxins.