Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits.
Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits.
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DOI：
10.1038/mp.2013.41
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发表时间：
2014-04
影响因子：
11
通讯作者：
Mill, J.
中科院分区：
文献类型：
--
作者：
Wong, C. C. Y.;Meaburn, E. L.;Ronald, A.;Price, T. S.;Jeffries, A. R.;Schalkwyk, L. C.;Plomin, R.;Mill, J.
自闭症谱系障碍（ASD）是一组常见的、复杂的神经发育障碍。虽然ASD的病因有很强的遗传成分，但有相当多的单卵（MZ）双胞胎不一致性表明非遗传因素的作用。由于同卵双胞胎共享相同的DNA序列，疾病不一致的同卵双胞胎对提供了一个理想的模型，用于检查疾病中环境驱动的表观遗传因素的贡献。我们对从代表性人群队列中抽样的50对MZ双胞胎（100人）样本进行了全基因组DNA甲基化分析，其中包括ASD、ASD相关特征和无自闭症表型不一致和一致的双胞胎。双胞胎内和组间分析确定了许多与ASD相关的差异甲基化区域。此外，我们报告了DNA甲基化和定量测量的自闭症特质分数之间的显着相关性在我们的样本队列。这项研究代表了第一个系统的表观基因组分析的MZ双胞胎不一致的ASD和牵连的作用，改变DNA甲基化在自闭症。
Autism spectrum disorder (ASD) defines a group of common, complex neurodevelopmental disorders. Although the aetiology of ASD has a strong genetic component, there is considerable monozygotic (MZ) twin discordance indicating a role for non-genetic factors. Because MZ twins share an identical DNA sequence, disease-discordant MZ twin pairs provide an ideal model for examining the contribution of environmentally driven epigenetic factors in disease. We performed a genome-wide analysis of DNA methylation in a sample of 50 MZ twin pairs (100 individuals) sampled from a representative population cohort that included twins discordant and concordant for ASD, ASD-associated traits and no autistic phenotype. Within-twin and between-group analyses identified numerous differentially methylated regions associated with ASD. In addition, we report significant correlations between DNA methylation and quantitatively measured autistic trait scores across our sample cohort. This study represents the first systematic epigenomic analyses of MZ twins discordant for ASD and implicates a role for altered DNA methylation in autism.
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影响因子：
3.5
作者：
Dempster EL;Pidsley R;Schalkwyk LC;Owens S;Georgiades A;Kane F;Kalidindi S;Picchioni M;Kravariti E;Toulopoulou T;Murray RM;Mill J
通讯作者：
Mill J
影响因子：
3.7
作者：
Karimi, Mohsen;Johansson, Sofia;Ekstrom, Tomas J.
通讯作者：
Ekstrom, Tomas J.
影响因子：
7
作者：
Gordon L;Joo JE;Powell JE;Ollikainen M;Novakovic B;Li X;Andronikos R;Cruickshank MN;Conneely KN;Smith AK;Alisch RS;Morley R;Visscher PM;Craig JM;Saffery R
通讯作者：
Saffery R
DOI：
10.1038/nrg3000
发表时间：
2011-07-12
期刊：
Nature reviews. Genetics
影响因子：
--
作者：
通讯作者：
--
影响因子：
9.3
作者：
Gregory SG;Connelly JJ;Towers AJ;Johnson J;Biscocho D;Markunas CA;Lintas C;Abramson RK;Wright HH;Ellis P;Langford CF;Worley G;Delong GR;Murphy SK;Cuccaro ML;Persico A;Pericak-Vance MA
通讯作者：
Pericak-Vance MA