PERSISTENCE OF INCREASED BONE-RESORPTION AND POSSIBLE ROLE OF DEHYDROEPIANDROSTERONE AS A BONE METABOLISM DETERMINANT IN OSTEOPOROTIC WOMEN IN LATE POST-MENOPAUSE
PERSISTENCE OF INCREASED BONE-RESORPTION AND POSSIBLE ROLE OF DEHYDROEPIANDROSTERONE AS A BONE METABOLISM DETERMINANT IN OSTEOPOROTIC WOMEN IN LATE POST-MENOPAUSE
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DOI：
10.1016/0378-5122(89)90121-7
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发表时间：
1989-03-01
期刊：
影响因子：
4.9
通讯作者：
VERMEULEN, A
中科院分区：
文献类型：
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作者：
TAELMAN, P;KAUFMAN, JM;VERMEULEN, A
有关绝经后晚期骨代谢的具体数据相对较少。这项研究提供了22名骨质疏松妇女的生化、激素和骨矿状况的数据，这些妇女至少有一处椎骨骨折，绝经后至少5年。超过三分之二的患者骨吸收参数升高。血清脱氢表雄酮及其硫酸盐水平与年龄、绝经年限呈负相关，与骨矿含量、骨转换参数(尿钙/肌酐、骨钙素)、1，25-二羟基-维生素D水平及1，25-二羟基-维生素D/25-羟基-维生素D比值呈正相关。这些发现表明，仔细评估绝经后晚期的骨转换率仍然对治疗决策有重要影响。他们还支持肾上腺雄激素在绝经后晚期的骨矿物质代谢中发挥作用的理论。
Specific data on bone metabolism in the late post-menopause are relatively scarce. This study presents data on the biochemical, hormonal and bone mineral status of a selected group of 22 osteoporotic women with at least 1 vertebral fracture who had been post-menopausal for a minimum of 5 yr. Bone resorption parameters were elevated in over two-thirds of these patients. The serum levels of dehydroepiandrosterone and its sulphate were negatively correlated with age and years since menopause but positiviely correlated with bone mineral content, bone turnover parameters (urinary calcium/creatinine, osteocalcin), 1,25-dihydroxy-vitamin D levels and the 1,25-dihydroxy-vitamin D/25-hydroxy-vitamin D ratio. These findings indicate that careful evaluation of the bone turnover rate in the late post-menopause can still have an important bearing on therapeutic decisions. They also support the theory that adrenal androgens play a role in bone mineral metabolism in the late post-menopause.