Reproducibility of Random Periareolar Fine Needle Aspiration in a Multi-institutional Cancer and Leukemia Group B (CALGB) Cross-Sectional Study
Reproducibility of Random Periareolar Fine Needle Aspiration in a Multi-institutional Cancer and Leukemia Group B (CALGB) Cross-Sectional Study
复制标题
DOI：
10.1158/1055-9965.epi-08-1210
复制
发表时间：
2009-05-01
影响因子：
3.8
通讯作者：
Seewaldt, Victoria L.
中科院分区：
文献类型：
--
作者：
Ibarra-Drendall, Catherine;Wilke, Lee G.;Seewaldt, Victoria L.
背景：随机乳晕周围细针抽吸（RPFNA）是一项研究技术，用于评估乳腺癌风险增加妇女的短期乳腺癌风险。虽然越来越多的人接受RPFNA，但RPFNA的可重复性和机构间兼容性尚未确定。为了解决这些关键的局限性，癌症和白血病B组（CALGB）预防组在一项多机构横断面研究中测试了RPFNA的可重复性。方法：2007年7月1日至2008年6月30日，来自5家CALGB机构（杜克大学、俄亥俄州立大学、罗斯威尔公园大学、达纳法伯大学和佛蒙特州）的63名高危妇女接受了RPFNA。由一名调查员在一天内对每名妇女进行双侧重复RPFNA。马苏德细胞学指数评分由单盲细胞病理学家评估。结果：同一乳腺重复RPFNA样本的Masood细胞学指数评分具有高度的统计学一致性，Spearman相关系数为0.8312 （P < 0.0001）。重要的是，虽然来自同一乳房的重复样本是一致的，但来自相反乳房的重复样本之间缺乏一致性。结论：这项多机构研究表明，在合作组横断面试验中，RPFNA是一种高度可重复性的乳腺细胞学测量方法。RPFNA并没有显示出乳房之间的高度一致性，这表明乳腺癌的风险和进展可能以不同的速度发生在单个女性的乳房上。这些研究为未来基于rpfna的合作群体预防研究提供了原理证明。（癌症流行病学杂志，2009;18(5):1379-85）
Background: Random periareolar fine needle aspiration (RPFNA) is a research technique developed to assess short-term breast cancer risk in women at increased risk of breast cancer. Although there is increasing acceptance of RPFNA, neither the reproducibility nor the inter-institutional compatibility of RPFNA has been established. To address these key limitations, the Cancer and Leukemia Group B (CALGB) Prevention Group tested the reproducibility of RPFNA in a multi-institutional cross-sectional study.Methods: Sixty-three high-risk women from five CALGB institutions (Duke, Ohio State, Roswell Park, Dana Farber, and Vermont) underwent RPFNA from July 1, 2007 to June 30, 2008. Duplicate bilateral RPFNA was performed on each woman by a single investigator on a single day. Masood Cytology Index score was assessed by a single blinded cytopathologist.Results: There was a high degree of statistical agreement in the Masood Cytology Index scores of duplicate RPFNA samples from the same breast, with a Spearman correlation coefficient of 0.8312 (P < 0.0001). Importantly, although there was agreement in duplicate samples from the same breast, there was lack of agreement between duplicate samples from the opposite breast.Conclusions: This multi-institutional study shows that RPFNA is a highly reproducible measure of breast cytology in a cooperative group cross-sectional trial. RPFNA did not show a high degree of agreement between breasts, suggesting that breast cancer risk and progression may occur at different rates in individual breasts from a single woman. These studies provide proof-of-principle for future RPFNA-based cooperative group prevention studies. (Cancer Epidemiol Biomarkers Prev 2009;18(5):1379-85)