Prenatal diagnosis of fetal skeletal dysplasias by combining two-dimensional and three-dimensional ultrasound and intrauterine three-dimensional helical computer tomography
Prenatal diagnosis of fetal skeletal dysplasias by combining two-dimensional and three-dimensional ultrasound and intrauterine three-dimensional helical computer tomography
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DOI：
10.1002/uog.1113
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发表时间：
2004-08-01
影响因子：
7.1
通讯作者：
Ville, Y
中科院分区：
文献类型：
--
作者：
Ruano, R;Molho, M;Ville, Y
目的评价新的影像学技术在骨骼发育不良产前诊断中的作用。方法2003年5月至10月，在一个转诊中心进行了前瞻性研究。对6例骨骼发育不良患者在二维超声（2D-US）检查后进行三维超声（3D-US）和三维螺旋CT（3D-HCT）检查。结果3例软骨发育不全，2例成骨不全H型，1例点状软骨发育不良。5例终止妊娠，1例Ⅱ型成骨肉瘤胎儿经剖宫产足月分娩。2D-US诊断正确4例。3D-US和3D-HCT对6例患者均作出了准确的诊断。3D-HCT和3D-US比2D-US（3D-HCT. 94.3%（33/35）; 3D-US：77.1%（27/35）; 2D-US：51.4%（18/35）; P < 0.01）。所有病例的诊断均在妊娠27 - 36周之间作出。结论3D-US和3D-HCT是2D-US的有效补充，可提高骨骼疾病产前诊断的准确性。这些新的成像技术可能在产前多学科方法诊断骨骼发育不良中发挥作用。版权所有（C）2004 ISUOG.出版社：John Wiley & Sons，Ltd
Objective To evaluate the contribution of new imaging techniques in the prenatal diagnosis of skeletal dysplasia.Methods Between May and October 2003, a prospective study was conducted in a single referral center. Three-dimensional ultrasound (3D-US) and three-dimensional helical computer tomography (3D-HCT) were performed after two-dimensional ultrasound (2D-US) in six cases of skeletal dysplasia. Diagnostic accuracy and detailed findings with each of the three techniques were compared with postnatal radiological findings.Results There were three cases of achondroplasia, two cases of osteogenesis imperfecta type H and one case of chondrodysplasia punctata. Termination of pregnancy was performed in five cases and one fetus with osteogenesis imperfecta type II was delivered at term by Cesarean section. 2D-US made the correct diagnosis in four cases. 3D-US and 3D-HCT achieved an accurate diagnosis in all six cases. 3D-HCT and 3D-US identified significantly more abnormalities than did 2D-US (3D-HCT. 94.3% (33/35); 3D-US: 77.1% (27/35); 2D-US: 51.4% (18/35); P < 0.01). The diagnosis was made between 27 and 36 weeks' gestation in all cases. The advantage of 3D-HCT over 3D-US was the possibility of imaging the entire fetus.Conclusion 3D-US and 3D-HCT seem to be useful complementary methods to 2D-US, and may improve accuracy of the prenatal diagnosis of skeletal disorders. These new imaging technologies may have a role in the prenatal multidisciplinary approach to the diagnosis of skeletal dysplasias. Copyright (C) 2004 ISUOG. Published by John Wiley & Sons, Ltd.