Polarization of the human motor cortex through the scalp
Polarization of the human motor cortex through the scalp
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DOI：
10.1097/00001756-199807130-00020
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发表时间：
1998-07-13
期刊：
影响因子：
1.7
通讯作者：
Manfredi, M
中科院分区：
文献类型：
--
作者：
Priori, A;Berardelli, A;Manfredi, M
直接施加到中枢神经系统结构的直流电 (DC) 在动物实验中会产生显着且持久的影响。我们通过评估经颅磁脑刺激引起的运动电位的变化，测试了非常弱的头皮直流电（< 0.5 mA，7 s）对人类运动皮层的功能影响。我们对 15 名健康志愿者进行了四项不同的实验。我们的研究结果得出这样的结论：这种微弱的（< 0.5 mA）阳极头皮直流电与阴极直流电交替，显着抑制了人类运动皮层的兴奋性，这提供了小电场穿过头骨并影响大脑的证据。头皮 DC 的一个可能的作用机制是人类运动皮层浅表兴奋性中间神经元的超极化。神经报告 9：2257-2260 (C) 1998 Rapid Science Ltd.
DIRECT currents (DC) applied directly to central nervous system structures produce substantial and longlasting effects in animal experiments. We tested the functional effects of very weak scalp DC (< 0.5 mA, 7 s) on the human motor cortex by assessing the changes in motor potentials evoked by transcranial magnetic brain stimulation. We performed four different experiments in 15 healthy volunteers. Our findings led to the conclusion that such weak (< 0.5 mA) anodal scalp DC, alternated with a cathodal DC, significantly depresses the excitability of the human motor cortex, providing evidence that a small electric field crosses the skull and influences the brain. A possible mechanism of action of scalp DC is the hyperpolarization of the superficial excitatory interneurones in the human motor cortex. Neuro Report 9: 2257-2260 (C) 1998 Rapid Science Ltd.