Long-term response of juvenile idiopathic arthritis after conditioning with 8 Gy total body irradiation followed by autologous peripheral blood stem cells: case report.
Long-term response of juvenile idiopathic arthritis after conditioning with 8 Gy total body irradiation followed by autologous peripheral blood stem cells: case report.
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幼年特发性关节炎经 8 Gy 全身照射后自体外周血干细胞调理后的长期反应：病例报告。
DOI：
10.1111/j.1399-3046.2009.01129.x
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发表时间：
2010
影响因子：
1.3
通讯作者：
Wallace,Carol
中科院分区：
文献类型：
--
作者：
Woolfrey,Ann;Storek,Jan;Bowyer,Suzanne;Nelson,Robert;Robertson,Michael;Wallace,Carol
[10]杨文，杨文.青少年特发性关节炎在接受8戈伊全身照射后接受自体外周血干细胞治疗的长期反应：病例报告。儿科移植2010：14：E65-E69。
© 2009 John Wiley & Sons A/S.摘要：针对难治性JIA的HCT研究采用了高剂量免疫抑制药物，例如CY和ATG，伴或不伴低剂量TBI。在大约三分之二的患者中观察到初始疾病缓解;然而，大约一半的缓解者发生复发。目前的报告描述了一个方案，大大增加剂量的TBI，以前被证明是与高率的疾病反应的成年患者难治性MS和严重的SSc。我们报告的结果，在这项试点研究中，谁仍然在完全缓解，现在，五年后HCT。对于药物治疗（包括既往低强度方案HCT）难治性JIA患者，应考虑使用该方案。
Woolfrey A, Storek J, Bowyer S, Nelson R, Robertson M, Wallace C. Long‐term response of juvenile idiopathic arthritis after conditioning with 8 Gy total body irradiation followed by autologous peripheral blood stem cells: Case report.
Pediatr Transplantation 2010: 14:E65–E69. © 2009 John Wiley & Sons A/S.Abstract:Investigations of HCT for refractory JIA have employed high dose immunosuppressive drugs, such as CY and ATG with or without low dose TBI. Initial disease response has been observed in approximately two‐thirds of patients; however, relapse occurs in about half of the responders. The current report describes a regimen with substantially increased dose of TBI, previously shown to be associated with high rate of disease response in adult patients with refractory MS and severe SSc. We report outcome of the lead patient in this pilot study, who remains in complete remission now, five yr after HCT. This regimen should be considered for patients with JIA refractory to medical therapies, including previous low intensity regimen HCT.