Hepatic portal infusion of glucagon antibodies increases spontaneous meal size in rats.
Hepatic portal infusion of glucagon antibodies increases spontaneous meal size in rats.
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肝门输注胰高血糖素抗体可增加大鼠自发进食量。
DOI：
10.1152/ajpregu.1991.261.1.r162
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Geary,N
中科院分区：
文献类型：
--
作者：
LeSauter,J;Noh,U;Geary,N
在随意喂养的雄性sd大鼠自食后的前2分钟内静脉注射足以中和体外1.5 ng胰高血糖素的特异性胰高血糖素抗体。在单独的试验中，胰高血糖素抗体在黑暗期的第一次自发进食（平均食量增加73%）和黑暗期最后四分之一的自发进食（增加58%）时刺激进食。这些结果表明胰高血糖素敏感饱腹机制在大鼠夜间摄食控制中具有生理作用。
Specific antibodies to pancreatic glucagon in a dose sufficient to neutralize 1.5 ng glucagon in vitro were intraportally infused during the first 2 min of spontaneous meals in ad libitum-fed male Sprague-Dawley rats. In separate tests, glucagon antibodies stimulated feeding during the first spontaneous meal of the dark phase (73% mean increase in meal size) and during spontaneous meals in the last quarter of the dark phase (58% increase). These results indicate that a glucagon-sensitive satiety mechanism has a physiological role in the control of nocturnal feeding in rats.