Alterations in magnesium and oxidative status during chronic emotional stress.
Alterations in magnesium and oxidative status during chronic emotional stress.
复制标题
慢性情绪压力期间镁和氧化状态的变化。
作者：
I. Cernak;V. Savic;J. Kotur;V. Prokić;B. Kuljić;D. Grbović;M. Veljović
研究人员对暴露于慢性压力（政治不容忍、对潜在军事袭击的认识、长期待命和减少假期超过10年）或亚慢性压力（包括持续超过3个月的军事行动中的日常致命危险）的年轻志愿者的镁和氧化状态进行了调查。两组中血浆离子化 Mg2+、总镁和离子化 Ca2+ 浓度均显着降低。同样，两个研究组都表现出氧化应激，通过血浆超氧阴离子和丙二醛的增加以及抗氧化防御的改变来评估。两个压力组之间没有显着差异。观察到镁平衡和氧化应激之间的负相关性，表明相同的病因（慢性应激）会导致游离镁和总镁浓度下降，同时增加氧化应激强度。这些发现支持生活在慢性压力条件下的人们需要补充镁和抗氧化维生素。
Magnesium and oxidative status were investigated in young volunteers exposed to chronic stress (political intolerance, awareness of potential military attacks, permanent stand-by duty and reduced holidays more than 10 years) or subchronic stress consisting of everyday mortal danger in military actions lasting more than 3 months. Significant decreases in plasma ionized Mg2+, total Mg and ionized Ca2+ concentrations were found in both groups. Similarly, both study groups exhibited oxidative stress as assessed by increased plasma superoxide anions and malondialdehyde and modified antioxidant defense. There were no significant differences between the two stress groups. A negative correlation between magnesium balance and oxidative stress was observed suggesting that the same etiological factor (chronic stress) initiate decreases in both free and total magnesium concentrations and simultaneously increase oxidative stress intensity. These findings support the need for magnesium supplementation with antioxidant vitamins for people living in conditions of chronic stress.