UNCOORDINATED PHYLOGEOGRAPHY OF BORRELIA BURGDORFERI AND ITS TICK VECTOR, IXODES SCAPULARIS
UNCOORDINATED PHYLOGEOGRAPHY OF BORRELIA BURGDORFERI AND ITS TICK VECTOR, IXODES SCAPULARIS
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DOI：
10.1111/j.1558-5646.2010.01001.x
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发表时间：
2010-09-01
期刊：
影响因子：
3.3
通讯作者：
Brisson, Dustin
中科院分区：
文献类型：
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作者：
Humphrey, Parris T.;Caporale, Diane A.;Brisson, Dustin
媒介传播的微生物必然与它们的宿主和媒介共同存在，但它们共享共同进化或地理历史的程度仍然未被探索。我们研究了莱姆病系统，在北美最流行的媒介传播的疾病的细菌和载体的进化和pepiographic历史的一致性。在美国东部和中西部，肩突硬蜱是导致莱姆病的伯氏疏螺旋体的主要载体。我们对16 S线粒体rDNA的地理学和人口学分析表明，北方I. scapularis种群起源于极少数来自美国东南部的移民，在更新世冰盖消退后，这些移民在东北部迅速扩张，随后在中西部扩张。尽管这种历史基因流，目前蜱迁移是有限的，即使在区域内的近端网站。相反，B. burgdorferi在东北部和中西部地区内没有基因流动的障碍，但显示出明显的区域间迁移障碍。尽管和B有着亲密的交往。伯格多费里和我肩胛带的种群结构、进化历史和历史地理都与其节肢动物媒介相反。在莱姆病的情况下，受感染的脊椎动物宿主的运动可能在病原体的当代扩张和均质化中发挥更大的作用，而不是蜱虫媒介的运动，蜱虫媒介的种群继续承受气候引起的范围转移的历史特征。
Vector-borne microbes necessarily co-occur with their hosts and vectors, but the degree to which they share common evolutionary or biogeographic histories remains unexplored. We examine the congruity of the evolutionary and biogeographic histories of the bacterium and vector of the Lyme disease system, the most prevalent vector-borne disease in North America. In the eastern and midwestern US, Ixodes scapularis ticks are the primary vectors of Borrelia burgdorferi, the bacterium that causes Lyme disease. Our phylogeographic and demographic analyses of the 16S mitochondrial rDNA suggest that northern I. scapularis populations originated from very few migrants from the southeastern US that expanded rapidly in the Northeast and subsequently in the Midwest after the recession of the Pleistocene ice sheets. Despite this historical gene flow, current tick migration is restricted even between proximal sites within regions. In contrast, B. burgdorferi suffers no barriers to gene flow within the northeastern and midwestern regions but shows clear interregional migration barriers. Despite the intimate association of B. burgdorferi and I. scapularis, the population structure, evolutionary history, and historical biogeography of the pathogen are all contrary to its arthropod vector. In the case of Lyme disease, movements of infected vertebrate hosts may play a larger role in the contemporary expansion and homogenization of the pathogen than the movement of tick vectors whose populations continue to bear the historical signature of climate-induced range shifts.