Synthesis of oxazoles through Pd-catalyzed cycloisomerization-allylation of N-propargylamides with allyl carbonates
Synthesis of oxazoles through Pd-catalyzed cycloisomerization-allylation of N-propargylamides with allyl carbonates
复制标题
DOI：
10.1016/j.tetlet.2010.01.018
复制
发表时间：
2010-03-17
影响因子：
1.8
通讯作者：
Hanzawa, Yuji
中科院分区：
文献类型：
--
作者：
Saito, Akio;Iimura, Koichi;Hanzawa, Yuji
在Pd-2（dba）（3）-Cy 3 P催化剂、IPr中心点HCl盐[IPr = 1，3-双（2，6-二异丙基苯基）咪唑-2-亚基]和Cs2 CO 3存在下，N-炔丙基芳基与碳酸烯丙酯通过环异构化-烯丙基化串联反应，合成了含高烯丙基的2，5-二取代恶唑。(C)2010爱思唯尔有限公司保留所有权利。
In the presence of Pd-2(dba)(3)-Cy3P catalyst, IPr center dot HCl salt [IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene], and Cs2CO3, N-propargylarnicles react with allyl carbonates to give 2,5-disubstituted oxazoles having homoallyl groups through the tandem cycloisomerization-allylation. (C) 2010 Elsevier Ltd. All rights reserved.