Physiology of glucose counterregulation to hypoglycemia
Physiology of glucose counterregulation to hypoglycemia
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DOI：
10.1016/s0889-8529(05)70083-9
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发表时间：
1999-09-01
影响因子：
4.5
通讯作者：
Fanelli, CG
中科院分区：
文献类型：
--
作者：
Bolli, GB;Fanelli, CG
预防低血糖对于保护大脑代谢和整个身体的生存至关重要。通常，葡萄糖是大脑用来满足其代谢需求的唯一底物。因此，循环葡萄糖的持续供应是正常脑代谢的必要先决条件。当血浆葡萄糖浓度降低时（例如，在长时间禁食期间或在施用降糖药物之后）激活几种生理反应以防止血糖的进一步降低。第一种反应被称为反调节，这是一种通过释放反调节激素来预防和纠正低血糖的系统。
Prevention of hypoglycemia is essential for the preservation of brain metabolism and survival of the whole body. Normally, glucose is the only substrate used by the brain to meet its metabolic requirements. Therefore, a continuous supply of circulatory glucose is a necessary prerequisite for normal cerebral metabolism. When plasma glucose concentration decreases (e.g., during prolonged fasting or after administration of glucose-lowering drugs) several physiologic responses are activated to prevent further decreases in blood glucose. The first response is known as counterregulation, a system that prevents and corrects hypoglycemia through the release of counterregulatory hormones.