EVIDENCE FOR AN ENVIRONMENTAL-EFFECT IN THE ETIOLOGY OF INSULIN-DEPENDENT DIABETES IN A TRANSMIGRATORY POPULATION
EVIDENCE FOR AN ENVIRONMENTAL-EFFECT IN THE ETIOLOGY OF INSULIN-DEPENDENT DIABETES IN A TRANSMIGRATORY POPULATION
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DOI：
10.1136/bmj.304.6833.1020
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发表时间：
1992-04-18
影响因子：
--
通讯作者：
CARTWRIGHT, R
中科院分区：
文献类型：
--
作者：
BODANSKY, HJ;STAINES, A;CARTWRIGHT, R
目的--研究从儿童糖尿病发病率低的地区搬到发病率高的地区的家庭的儿童是否表现出相应的发病率上升。设计--12年的疾病发病率研究。设置--布拉德福德区大都会理事会地区。对象--所有0-16岁的研究对象居住在研究地区。主要结果测量--亚洲和非亚洲儿童糖尿病的发病率。亚洲家庭。结果-糖尿病在亚洲儿童的发病率从1978-81年的3.1/100000每年增加到1988-90年的11.7/100000每年（趋势卡方= 4.95，df = 1，p = 0.026），而其他儿童保持不变，每年10.5/100000。在整个研究期间，亚洲女性的发病率较低（4.9/100000/年）（8.8/100000/年），而其他儿童则相反（男性每年9.2/100000;女性每年12.0/100000）（常见优势比检验：chi-2 = 3.81，df = 1，p = 0.052）。结论-该移民人口的后代儿童糖尿病发病率上升，接近土著人口。这些数据为胰岛素依赖型糖尿病的病因学中的环境效应提供了强有力的证据。
Objective - To examine whether children of families moving from an area of low incidence of childhood diabetes to one which is higher show a corresponding rise in disease incidence.Design - Disease incidence study over 12 years.Setting - Bradford District Metropolitan Council area.Subjects - All subjects aged 0-16 years resident within the study area.Main outcome measures - The incidences of childhood diabetes in Asian and non-Asian families.Results - The incidence of diabetes in Asian children increased from 3.1/100000 per year in 1978-81 to 11.7/100000 per year in 1988-90 (chi-2 for trend = 4.95, df = 1, p = 0.026) whereas that for other children remained constant at 10.5/100000 per year. Over the entire study period rates were lower in Asian females (4.9/100000 per year) than in Asian males (8.8/100000 per year) whereas the reverse was true for other children (males 9.2/100000 per year; females 12.0/100000 per year) (test for common odds ratio: chi-2 = 3.81, df = 1, p = 0.052).Conclusions - Offspring of this transmigratory population had a rising incidence of childhood diabetes which was approaching that of the indigenous population. The data provide strong evidence for an environmental effect in the aetiology of insulin dependent diabetes.