RSV bronchiolitis and risk of wheeze and allergic sensitisation in the first year of life
RSV bronchiolitis and risk of wheeze and allergic sensitisation in the first year of life
复制标题
DOI：
10.1183/09031936.02.00019902
复制
发表时间：
2002-11-01
影响因子：
24.3
通讯作者：
Stephan, V
中科院分区：
文献类型：
--
作者：
Schauer, U;Hoffjan, S;Stephan, V
严重呼吸道合胞病毒（RSV）感染被假设为过敏和哮喘发生的危险因素，但在年龄较大的儿童中的流行病学研究尚未得出结论。目前的研究假设RSV细支气管炎的影响可能在细支气管炎后的第一年最为突出。42名婴儿经历了严重到足以导致住院的RSV细支气管炎。对于每个RSV感染的儿童，从出生队列中获得两个对照，并匹配出生日期和性别。所有的儿童进行了前瞻性随访，并在平均年龄为1岁时进行了随访检查，包括体格检查，血清免疫球蛋白（IG）E测试，以确定常见的食物和吸入性过敏原。对照组42例RSV患儿中14例（33%）和84例患儿中2例（2.3%）IgE抗体检测阳性。RSV细支气管炎是过敏性致敏的最重要危险因素。同样，13名儿童（15.5%）的RSV组和3名（3.6%）的对照组患有反复喘息，RSV毛细支气管炎构成了相当大的风险反复喘息。严重的呼吸道合胞病毒毛细支气管炎在生命的第一年是一个重要的危险因素，在随后的一年反复喘息和常见的过敏原的敏感性的发展。
Severe respiratory syncytial virus (RSV) infection has been hypothesised to be a risk factor for the development of allergy and asthma, but epidemiological studies in older children have been inconclusive. The current study hypothesises that the effect of RSV bronchiolitis might be most prominent during the first year after bronchiolitis.Forty-two infants had experienced RSV bronchiolitis severe enough to cause hospitalisation. For each child with RSV infection, two controls were acquired from a birth cohort and matched for date of birth and sex. All the children were followed prospectively and underwent a follow-up examination at a mean age of I yr, which included physical examination, and serum immunoglobulin (Ig) E tests for common food and inhaled allergens.Risk factors for the development of recurrent wheezing and IgE antibodies were analysed for the whole group of 126 children. A positive test for IgE antibodies was noted in 14 of 42 (33%) RSV children and in 2 of 84 (2.3%) children in the control group. RSV bronchiolitis was the most important risk factor for allergic sensitisation. Likewise, 13 children (15.5%) of the RSV group and three (3.6%) children of the control group suffered from recurrent wheezing, and RSV bronchiolitis posed a considerable risk for recurrent wheezing.Severe respiratory syncytial virus bronchiolitis during the first year of life is an important risk factor for the development of recurrent wheezing and sensitisation to common allergens during the subsequent year.