The inhibition of long-term potentiation in the rat dentate gyrus by pro-inflammatory cytokines is attenuated in the presence of nicotine
The inhibition of long-term potentiation in the rat dentate gyrus by pro-inflammatory cytokines is attenuated in the presence of nicotine
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DOI：
10.1016/s0304-3940(03)00440-3
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发表时间：
2003-06-26
影响因子：
2.5
通讯作者：
O'Connor, JJ
中科院分区：
文献类型：
--
作者：
Curran, BP;O'Connor, JJ
尼古丁以前已被证明影响长时程增强（LTP）和长时程。抑郁症和逆转海马中与年龄相关的LTP损伤。已知促炎细胞因子的水平随着年龄的增长而升高，并抑制LTP。在本研究中，我们研究了三种促炎细胞因子对尼古丁增强的体外大鼠海马LTP的影响。在尼古丁的存在下，白细胞介素-1 β，白细胞介素-18和肿瘤坏死因子-α对LTP的抑制作用被消除。此外，建立LTP显着的去增强不能得到与尼古丁处理的切片。这些实验表明，尼古丁可以逆转促炎细胞因子对LTP的抑制作用。(C)2003爱思唯尔科学爱尔兰有限公司保留所有权利。
Nicotine has previously been shown to affect both long-term potentiation (LTP) and long-term. depression and to reverse age-related impairments of LTP in the hippocampus. Levels of proinflammatory cytokines are known to be elevated with age and to inhibit LTP. In the present study we have investigated the effects of three pro-inflammatory cytokines on nicotine-enhanced LTP in the rat hippocampus in vitro. In the presence of nicotine the inhibitory effect of interleukin-1beta, interleukin-18 and tumour necrosis factor-alpha on LTP was eliminated. Furthermore, significant depotentiation of established LTP could not be obtained in slices treated with nicotine. These experiments demonstrate that nicotine can reverse the inhibitory effects of pro-inflammatory cytokines on LTP. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.