Strategies for the Advancement of Surgical Methods in Cleft Lip and Palate
Strategies for the Advancement of Surgical Methods in Cleft Lip and Palate
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唇腭裂手术方法的改进策略
DOI：
10.1597/1545-1569_1991_028_0141_sftaos_2.3.co_2
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
W. Shaw
中科院分区：
文献类型：
--
作者：
C. Roberts;G. Semb;W. Shaw
本文探讨了临床研究方法用于唇腭裂治疗的评价。对1964年至1988年《腭裂杂志》上的临床报告进行的一项调查显示，几乎所有的报告都使用了回顾性方法（96%）。作者研究了与回顾性治疗评价相关的优点和偏倚，并将其与前瞻性随机临床试验进行了比较。临床试验的优点和缺点进行了讨论，在有关的长期评价唇腭裂患者的初次手术。为了使这些研究取得成功，还需要进一步研究样本量、长期预后的可能预测因素以及术前评估的改进方法等问题。作者得出结论，如果要解决与选择初次腭裂手术相关的不确定性，那么参与腭裂临床研究的各个学科必须面对多中心前瞻性临床试验的挑战。
This paper examines the clinical research methodologies used for the evaluation of cleft lip and palate therapies. A survey of clinical reports in the Cleft Palate Journal between 1964 and 1988 revealed that almost all used retrospective methods (96%). The authors examine the merits and biases associated with retrospective evaluation of therapies and compare these to prospective randomized clinical trials. The strengths and weaknesses of clinical trials are discussed in relation to the long-term evaluation of primary surgery in cleft patients. For these to be successful, further work is needed to investigate questions such as sample size, possible predictors of long-term outcome, and improved methods of presurgical assessment. The authors conclude that if the uncertainties associated with the choice of primary cleft surgery are to be resolved, the challenge of multicenter prospective clinical trials must be faced by the various disciplines involved in cleft palate clinical research.