Remodeling the tumor microenvironment by oncolytic viruses: beyond oncolysis of tumor cells for cancer treatment.
Remodeling the tumor microenvironment by oncolytic viruses: beyond oncolysis of tumor cells for cancer treatment.
复制标题
DOI：
10.1136/jitc-2021-004167
复制
发表时间：
2022-05
影响因子：
10.9
通讯作者：
中科院分区：
文献类型：
--
作者：
肿瘤细胞操纵它们生长的局部环境，创造促进肿瘤存活和转移的肿瘤微环境（TME）。TME是一个极其复杂的环境，富含免疫抑制细胞和细胞因子。治疗靶向复杂TME的各种方法正在成为癌症治疗的潜在方法。溶瘤病毒（OV）是将TME重塑为抗肿瘤环境的最有前途的方法之一，可以单独使用或与其他免疫治疗方案联合使用。OV在肿瘤细胞中特异性复制，并且可以被遗传工程化以同时靶向TME的多个元件，因此代表了具有修饰TME以促进抗肿瘤免疫细胞的活化并克服肿瘤治疗抗性和复发的潜力的治疗剂。在这篇综述中，我们分析了OVs对肿瘤细胞的向性，并详细探讨了OVs与免疫细胞、肿瘤基质、血管系统和代谢环境之间的相互作用，以帮助理解OVs如何成为我们最有前途的长期治愈性治疗方法之一。我们还讨论了与TME疗法相关的一些挑战，以及这个不断发展的领域的未来前景。
Tumor cells manipulate the local environment in which they grow, creating a tumor microenvironment (TME) that promotes tumor survival and metastasis. The TME is an extremely complex environment rich in immunosuppressive cells and cytokines. Various methods to therapeutically target the complicated TME are emerging as a potential approach for cancer treatment. Oncolytic viruses (OVs) are one of the most promising methods for remodeling the TME into an antitumor environment and can be used alone or in combination with other immunotherapy options. OVs replicate specifically in tumor cells and can be genetically engineered to target multiple elements of the TME simultaneously, thus representing a therapeutic with the potential to modify the TME to promote activation of antitumor immune cells and overcome tumor therapeutic resistance and recurrence. In this review, we analyze the tropism of OVs towards tumor cells and explore the interaction between OVs and immune cells, tumor stroma, vasculature and the metabolic environment in detail to help understand how OVs may be one of our most promising prospects for long-term curative therapies. We also discuss some of the challenges associated with TME therapies, and future perspectives in this evolving field.
登录
查看更多内容
影响因子：
5.4
作者：
BULLER, RML;CHAKRABARTI, S;MOSS, B
通讯作者：
MOSS, B
影响因子：
5.1
作者：
Dias, J. D.;Hemminki, O.;Hemminki, A.
通讯作者：
Hemminki, A.
影响因子：
21.3
作者：
Arwert EN;Milford EL;Rullan A;Derzsi S;Hooper S;Kato T;Mansfield D;Melcher A;Harrington KJ;Sahai E
通讯作者：
Sahai E
影响因子：
7.4
作者：
Ehrig K;Kilinc MO;Chen NG;Stritzker J;Buckel L;Zhang Q;Szalay AA
通讯作者：
Szalay AA
影响因子：
4.6
作者：
El-Sherbiny, Y. M.;Holmes, T. D.;Cook, G. P.
通讯作者：
Cook, G. P.