A FACILE SYNTHESIS OF 5,7-DIHYDRO-5-OXOPYRIDO[3',2'-5,6]PYRIMIDO[1,2-A]BENZIMIDAZOLES - A NEW HETEROCYCLIC RING-SYSTEM
A FACILE SYNTHESIS OF 5,7-DIHYDRO-5-OXOPYRIDO[3',2'-5,6]PYRIMIDO[1,2-A]BENZIMIDAZOLES - A NEW HETEROCYCLIC RING-SYSTEM
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DOI：
10.1002/jhet.5570230645
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发表时间：
1986-11-01
影响因子：
2.4
通讯作者：
PRIMOFIORE, G
中科院分区：
文献类型：
--
作者：
CAROTI, P;CECCOTTI, C;PRIMOFIORE, G
2 -氯吡啶- 3 -羰基氯与1 -烷基- 2 -氨基苯并咪唑反应生成theN -（1 -烷基苯并咪唑- 2 -酰基）- 2 -氯吡啶- 3 -羧酰胺，并环化为5,7 -二氢- 5 -氧吡啶[3′，2′：5,6]嘧啶[1,2 - a]苯并咪唑。这些迄今为止未知的杂环化合物的指定结构被它们的ir和1h核磁共振光谱和化学证据证实。
Reaction between 2‐chloropyridine‐3‐carbonyl chloride and 1‐alkyl‐2‐aminobenzimidazoles afforded theN‐(1‐alkylbenzimidazole‐2‐yl)‐2‐chloropyridine‐3‐carboxamides, which were cyclized to 5,7‐dihydro‐5‐oxopyrido[3′,2′:5,6]pyrimido[1,2‐a]benzimidazoles. The assigned structures of these hitherto unknown heterocyclic compounds were confirmed by their ir and1H nmr spectra and chemical evidence.