The first decade and beyond of transcriptional profiling in schizophrenia.
The first decade and beyond of transcriptional profiling in schizophrenia.
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DOI：
10.1016/j.nbd.2011.03.001
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发表时间：
2012-01
影响因子：
6.1
通讯作者：
Vawter, Marquis P.
中科院分区：
文献类型：
--
作者：
Sequeira, P. Adolfo;Martin, Maureen V.;Vawter, Marquis P.
关键词：
精神分裂症(SZ)患者大脑中基因表达的变化被假设为反映了与病理生理学和/或药物相关的可能途径。其他因素对大脑中的基因表达谱有很强的影响，并可能影响精神分裂症转录组，如年龄和pH。在SZ中已报道的基因表达或基因相关网络的通路(白质、细胞凋亡、神经发生、突触可塑性、谷氨酸和GABA能神经传递、免疫和应激反应、线粒体和神经发育)不是SZ独有的，并且与其他精神疾病有关。未来十年改进概况分析的建议：考虑仔细解剖的多个大脑区域，发布来自对照组多个大脑区域的大型数据集，以更好地了解神经电路，整合遗传学和基因表达，在全基因组水平上测量表达变异，进行外周生物标记物研究，并分析一系列大脑发育的转录组。基因表达虽然是基因组图景的一个重要特征，但需要进一步的系统生物学来从控制大脑发展到对精神分裂症相互作用体的更准确的定义。
Gene expression changes in brains of individuals with schizophrenia (SZ) have been hypothesized to reflect possible pathways related to pathophysiology and/or medication. Other factors have robust effects on gene expression profiling in brain and possibly influence the schizophrenia transcriptome such as age and pH are examined. Pathways of curated gene expression or gene correlation networks reported in SZ (white matter, apoptosis, neurogenesis, synaptic plasticity, glutamatergic and GABAergic neurotransmission, immune and stress-response, mitochondrial, and neurodevelopment) are not unique to SZ and have been associated with other psychiatric disorders. Suggestions going forward to improve the next decade of profiling: consider multiple brain regions that are carefully dissected, release large datasets from multiple brain regions in controls to better understand neurocircuitry, integrate genetics and gene expression, measure expression variants on genome wide level, peripheral biomarker studies, and analyze the transcriptome across a developmental series of brains. Gene expression, while an important feature of the genomic landscape, requires further systems biology to advance from control brains to a more precise definition of the schizophrenia interactome.
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影响因子：
4.5
作者：
Bauer, Deborah;Haroutunian, Vahram;Meador-Woodruff, James H.;McCullumsmith, Robert E.
通讯作者：
McCullumsmith, Robert E.
DOI：
10.1038/npp.2008.172
发表时间：
2009-01
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
10.6
作者：
Aoki-Suzuki, M;Yamada, K;Yoshikawa, T
通讯作者：
Yoshikawa, T
影响因子：
4.5
作者：
Barley, Kevin;Dracheva, Stella;Byne, William
通讯作者：
Byne, William
影响因子：
11
作者：
Camargo, L. M.;Collura, V.;Brandon, N. J.
通讯作者：
Brandon, N. J.