The organization of cerebellar cortical circuitry revisited - Implications for function
The organization of cerebellar cortical circuitry revisited - Implications for function
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DOI：
10.1111/j.1749-6632.2002.tb07562.x
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发表时间：
2002-01-01
期刊：
影响因子：
--
通讯作者：
Bower, JM
中科院分区：
文献类型：
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作者：
Bower, JM
超过35年来，有实验证据表明，平行纤维活动不会产生激活的浦肯野细胞束，这是基于皮质解剖学假设的，也是大多数小脑皮质功能理论所假设的。本文首先回顾了支持和反对平行纤维束假说的证据，然后讨论了我们最近的实验和基于模型的调查结果，旨在更好地了解平行纤维对浦肯野细胞的影响。这些研究的一个主要结论是，平行纤维对浦肯野细胞树突的兴奋作用是调制，必须考虑在分子层中间神经元提供的平衡抑制影响的背景下，这些相同的树突。有人提出，这种关联的兴奋和抑制可以解释缺乏梁样效应的浦肯野细胞。本文最后考虑的后果，这种新的解释小脑皮层电路目前的理论小脑功能。
For more than 35 years there has been experimental evidence that parallel fiber activity does not generate the beams of activated Purkinje cells hypothesized on the basis of cortical anatomy and assumed by most theories of cerebellar cortical function. This paper first reviews the evidence for and against the parallel fiber beam hypothesis, and then discusses the findings of our recent experimental and model-based investigations intended to better understand parallel fiber effects on Purkinje cells. A principal conclusion of these studies is that the excitatory effects of parallel fibers on Purkinje cell dendrites are modulating and must be considered in the context of a balancing inhibitory influence provided by molecular layer interneurons to these same dendrites. It is proposed that this association of excitation and inhibition can account for the lack of beam-like effects on Purkinje cells. The paper concludes by considering the consequences of this new interpretation of cerebellar cortical circuitry for current theories of cerebellar function.