Synthesis of skipped enynes via phosphine-promoted couplings of propargylcopper reagents
Synthesis of skipped enynes via phosphine-promoted couplings of propargylcopper reagents
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DOI：
10.1016/j.tet.2003.04.002
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发表时间：
2003-11-03
期刊：
影响因子：
2.1
通讯作者：
Jamison, TF
中科院分区：
文献类型：
--
作者：
Heffron, TP;Trenkle, JD;Jamison, TF
富电子膦添加剂对于炔丙基铜试剂和烯基卤化物的炔丙基选择性偶联是关键的并且是足够的。该方法是对先前描述的那些方法的补充，其中在类似的偶联反应中观察到高丙二烯基选择性。虽然磷化氢效应的基础需要进一步研究，但这些研究中获得的信息使得能够通过跳过的烯炔中间体合成复杂分子。(C)2003 Elsevier Ltd.保留所有权利。
An electron-rich phosphine additive is critical and sufficient for propargyl-selective couplings of propargylcopper reagents and alkenyl halides. This method is complementary to those previously described, in which high allenyl selectivity is observed in analogous coupling reactions. While the basis of the phosphine effect requires further investigation, the information gained in these studies enables the synthesis of complex molecules by way of skipped enyne intermediates. (C) 2003 Elsevier Ltd. All rights reserved.