Schizophrenia and the risk of cardiovascular diseases: A meta-analysis of thirteen cohort studies
Schizophrenia and the risk of cardiovascular diseases: A meta-analysis of thirteen cohort studies
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DOI：
10.1016/j.jpsychires.2013.07.011
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发表时间：
2013-11-01
影响因子：
4.8
通讯作者：
Zhan, Renya
中科院分区：
文献类型：
--
作者：
Fan, Zuoxu;Wu, Yaoyao;Zhan, Renya
背景资料：许多研究探讨了精神分裂症与心血管疾病（CVD）发病率之间的关系，但其结果并不完全一致。我们的研究旨在阐明精神分裂症和心血管疾病的风险之间的关联的荟萃分析队列study.Methods：PubMed，科克伦图书馆，和EMBASE数据库进行了检索，以确定相关的研究，符合预先规定的纳入标准。我们还审查了检索文章的参考文献列表。相对危险度（RR）和95%置信区间（CI）提取和合并使用的固定效应或随机效应models.Results：13项研究涉及3,549,950名参与者，与CVD的结果报告为422,698，被列入荟萃分析。随访时间为1.6 ~ 36.0年。荟萃分析发现，与参考组相比，精神分裂症的合并RR为1.53（95% CI：1.27-1.86）CVD发生率为1.20冠心病（CHD）、脑卒中和充血性心力衰竭（CHF）患者的平均生存时间分别为1.71（95% CI：1.19-2.46）和1.81（95% CI：1.42-2.29）。排除单个队列或使用未调整的RR后的敏感性分析得出的结果与主要总体估计值相似。结论：精神分裂症与心血管疾病、脑卒中和心力衰竭的发病率增加有关，也可能增加冠心病的风险。更多的关注。对精神分裂症患者应给予抗抑郁药，以预防心血管疾病的发生，降低心脏病的发病率。(C)2013爱思唯尔有限公司保留所有权利。
Background: Numerous studies have investigated the relationship between schizophrenia and the incidence of cardiovascular disease (CVD), but their results were not entirely consistent. Our study aimed to elucidate the association between schizophrenia and the risk of CVD by a meta-analysis of cohort studies.Methods: PubMed, the Cochrane Library, and EMBASE databases were searched to identify relevant studies that met the prespecified inclusion criteria. We also reviewed reference lists from the retrieved articles. Relative risks (RRs) and 95% confidence intervals (CIs) were extracted and pooled using the fixed-effect or random-effects models.Results: Thirteen studies involving 3,549,950 participants, with outcomes of CVD reported for 422,698, were included in the meta-analysis. The follow-up period ranged from 1.6 to 36.0 years. The meta-analysis found that the pooled RRs for schizophrenia compared with the reference group were 1.53 (95% CI: 1.27-1.86) for the incidence of CVD, 1.20 (95% CI: 0.93-1.53) for coronary heart disease (CHD), 1.71 (95% CI: 1.19-2.46) for stroke, and 1.81 (95% Cl: 1.42-2.29) for congestive heart failure (CHF). Sensitivity analysis after the exclusion of a single cohort or using the unadjusted RRs yielded similar results to the primary overall estimations. No evidence of publication bias was observed.Conclusions: Schizophrenia is associated with increased incidence of CVD, stroke and CHF, and might also increase the risk of CHD. Greater attention. should be paid to schizophrenia patients to prevent the occurrence of CVD and to decrease the risk of cardiac morbidity. (C) 2013 Elsevier Ltd. All rights reserved.