BIOSYNTHETIC RELATIONSHIPS AMONG THE SECALONIC ACIDS - ISOLATION OF EMODIN, ENDOCROCIN AND SECALONIC ACIDS FROM PYRENOCHAETA-TERRESTRIS AND ASPERGILLUS-ACULEATUS
BIOSYNTHETIC RELATIONSHIPS AMONG THE SECALONIC ACIDS - ISOLATION OF EMODIN, ENDOCROCIN AND SECALONIC ACIDS FROM PYRENOCHAETA-TERRESTRIS AND ASPERGILLUS-ACULEATUS
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DOI：
10.7164/antibiotics.32.1256
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发表时间：
1979-01-01
影响因子：
3.3
通讯作者：
MCINNES, AG
中科院分区：
文献类型：
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作者：
KUROBANE, I;VINING, LC;MCINNES, AG
从5株陆地假单胞菌中分离得到环孢菌素、大黄素、内生卡洛菌素和第二醛酸酸A、E和G。尖顶红曲霉产生大黄素、内皮卡菌素和第二醛酸B、D和F，未检测到胞苷。少量大黄素的分离支持了先前的证据，即大黄素是次丙酮酸生物合成的中间体。在其他生物体中与次生酸共同产生的胞苷和内毒素的分离表明，这些化合物是由共同的分支途径形成的。一个P.terrestris的自然分离株含有产生不同相对含量的Secalonic酸A、E和G的变异株。从目前所研究的生物体产生的Secalonic酸的组合中，得出结论：前体四氧杂菲单元仅在C-5或在反式不变的C-6：C-10a位置形成立体化学上不同的对。讨论了一种可能的生物合成途径。
Cynodontin, emodin, endocrocin and secalonic acids A, E and G were isolated from 5 strains of P. terrestris. A. aculeatus produces emodin, endocrocin and secalonic acids B, D and F. No cynodontin was detected. Isolation of emodin in small amounts supports previous evidence that it is an intermediate in secalonic acid biosynthesis. Isolation of cynodontin and endocrocin, which are coproduced with secalonic acids in other organisms, suggests that these compounds are formed by a common branching pathway. A natural isolate of P. terrestris contained variant strains which produced different relative amounts of secalonic acids A, E and G. From the combinations of secalonic acids produced in organisms so far examined it is concluded that precursor tetrahydroxanthone units are formed in pairs differing in stereochemistry only at C-5 or at the trans-invariant C-6:C-10a positions. A possible biosynthetic pathway is discussed.