The importance of housing conditions on behavioral sensitization and tolerance to ethanol
The importance of housing conditions on behavioral sensitization and tolerance to ethanol
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DOI：
10.1016/j.pbb.2005.07.009
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发表时间：
2005-09-01
影响因子：
3.6
通讯作者：
Frussa-Filho, R
中科院分区：
文献类型：
--
作者：
Araujo, NP;Camarini, R;Frussa-Filho, R
研究了社会隔离和拥挤环境对单次或多次给药乙醇对雌鼠野外行为影响的不同结果。虽然住房条件没有改变乙醇单次给药引起的运动活动的增加，但与孤立组和对照组相比，拥挤小鼠对乙醇运动激活效应的行为致敏性（反复给药后药物作用的逐渐增加）明显更大。单次施用乙醇显著降低了饲养频率，增加了静止时间，重复施用后对这些乙醇行为影响具有耐受性。经反复处理证实，社会隔离可减弱单次给药乙醇引起的固定行为增加，并增强乙醇诱导的饲养减少耐受性。这些结果指出，对乙醇行为影响的敏感性和耐受性都可能受到住房条件的严重影响。(c) 2005爱思唯尔公司版权所有。
The differential outcomes of social isolation and crowding environment on the effects of single or repeated administration of ethanol on open-field behavior were examined in female mice. Whereas housing conditions did not alter the increase in locomotor activity induced by ethanol single administration, behavioral sensitization (a progressive increase of a drug effect following repeated drug administration) to the locomotor activating effect of ethanol was significantly greater in crowded mice as compared to isolated and control groups. Single administration of ethanol significantly decreased rearing frequency and increased immobility duration, there being tolerance to these ethanol behavior effects after repeated treatment. Social isolation attenuated the increase in immobility behavior induced by single administration of ethanol and potentiated the tolerance of ethanol-induced rearing decrease, verified after repeated treatment. These results point out that both sensitization and tolerance to the behavioral effects of ethanol can be critically influenced by housing conditions. (c) 2005 Elsevier Inc. All rights reserved.