Regulation of bone formation by bone morphogenetic proteins and other growth factors.
Regulation of bone formation by bone morphogenetic proteins and other growth factors.
复制标题
骨形态发生蛋白和其他生长因子对骨形成的调节。
DOI：
10.1097/00003086-199603000-00004
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发表时间：
1996
影响因子：
4.2
通讯作者：
Mundy,GR
中科院分区：
文献类型：
--
作者：
Mundy,GR
成人的骨形成是一个复杂而受严格调控的过程。它通常发生在先前破骨细胞骨吸收的部位。它也可能发生在生长中的长骨软骨内骨形成过程中，也可能出现在生长和青春期，没有预先的局部吸收，特别是在骨膜表面。参与骨形成的细胞事件包括成骨细胞前体的趋化；成骨细胞前体的增殖；分化，包括骨生长调节因子和骨结构蛋白的表达，如骨钙素、骨桥蛋白和I型胶原；和矿化。很明显，这些细胞事件必须受到非常严格的调控控制。它们都可能受到全身激素的调节，包括嗜钙化激素、甲状旁腺激素和1,25二羟维生素D以及其他全身激素，如垂体、甲状腺激素和性类固醇，但可能主要受骨细胞微环境中产生的局部因子或细胞因子的调节。
Bone formation in adult humans is a complex and closely regulated process. It usually occurs at sites of previous osteoclastic bone resorption. It also may occur in the growing long bones during endochondral bone formation, and appositional bone formation also can appear during growth and adolescence without prior local resorption, particularly on periosteal surfaces. The cellular events involved in bone formation include chemotaxis of osteoblast precursors; proliferation of committed osteoblast precursors; differentiation, including expression of growth regulatory factors and the structural proteins of bone, such as osteocalcin, osteopontin, and Type I collagen; and mineralization. It is clear that these cellular events must be under very tight regulatory control. They may all be modulated by systemic hormones, including the calciotropic hormones, parathyroid hormone and 1, 25 dihydroxyvitamin D and other systemic hormones, such as the pituitary and thyroid hormones and sex steroids, but probably are modulated predominantly by local factors or cytokines generated in the bone cell microenvironment.