Non-invasive Central and Peripheral Stimulation: New Hope for Essential Tremor?
Non-invasive Central and Peripheral Stimulation: New Hope for Essential Tremor?
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非侵入性中心和外围刺激：基本震颤的新希望？
DOI：
10.3389/fnins.2015.00440
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发表时间：
2015
影响因子：
4.3
通讯作者：
Ayache SS
中科院分区：
文献类型：
--
作者：
Chalah MA;Lefaucheur JP;Ayache SS
原发性震颤（ET）是最常见的运动障碍之一。它通常表现为手臂的体位性和运动性震颤，但也可能涉及头部、声音、下肢和躯干。振荡网络被认为是ET的神经关联，主要由橄榄小脑系统、丘脑和运动皮层组成。由于药物治疗的效果有限，像深部脑刺激这样的手术干预是最严重病例的最后一线治疗选择。非侵入性脑刺激技术，特别是经颅磁刺激或直流电刺激，被用来改善ET。它们的非侵入性，以及它们的副作用，使它们成为一种有吸引力的治疗选择。此外，外周刺激也被应用于相同的角度。因此，本综述的目的是阐明在这种有趣的背景下，非侵入性中枢和外周刺激技术的紧急使用。
Essential tremor (ET) is among the most frequent movement disorders. It usually manifests as a postural and kinematic tremor of the arms, but may also involve the head, voice, lower limbs, and trunk. An oscillatory network has been proposed as a neural correlate of ET, and is mainly composed of the olivocerebellar system, thalamus, and motor cortex. Since pharmacological agents have limited benefits, surgical interventions like deep brain stimulation are the last-line treatment options for the most severe cases. Non-invasive brain stimulation techniques, particularly transcranial magnetic or direct current stimulation, are used to ameliorate ET. Their non-invasiveness, along with their side effects profile, makes them an appealing treatment option. In addition, peripheral stimulation has been applied in the same perspective. Hence, the aim of the present review is to shed light on the emergent use of non-invasive central and peripheral stimulation techniques in this interesting context.