Immune regulation of therapy-resistant niches: emerging targets for improving anticancer drug responses.
Immune regulation of therapy-resistant niches: emerging targets for improving anticancer drug responses.
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治疗抵抗生态位的免疫调节：改善抗癌药物反应的新兴目标。
DOI：
10.1007/s10555-014-9501-9
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Jinushi M
中科院分区：
文献类型：
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作者：
小井詰 史朗;伊藤 慎;吉原 光代;中村 圭靖;宮城 悦子;平原 史樹;高野 康雄;宮城 洋平;Jinushi M
新出现的证据揭示了免疫学参数在预测肿瘤预后和对抗癌治疗的临床反应中的关键作用。另一方面，对抗癌药物的反应性极大地改变了肿瘤浸润免疫细胞的库、表型和免疫原性，作为调节致瘤活性和治疗抗性表型出现的关键因素。肿瘤相关的免疫功能受到不同或重叠的治疗方式的影响，例如细胞毒性化疗，放疗或分子靶向治疗，并且各种抗癌方式具有独特的特性，以影响肿瘤微环境中肿瘤细胞和免疫细胞之间的串扰模式。因此，了解精确的分子机制是至关重要的，其中每种抗癌策略在调节肿瘤微环境中肿瘤和免疫细胞之间相互通讯的动态性方面具有独特或重叠的作用。这种理解将通过利用免疫系统克服对传统抗癌药物的耐药性来开辟新的治疗机会。
Emerging evidence has unveiled a critical role for immunological parameters in predicting tumor prognosis and clinical responses to anticancer therapeutics. On the other hand, responsiveness to anticancer drugs greatly modifies the repertoires, phenotypes, and immunogenicity of tumor-infiltrating immune cells, serving as a critical factor to regulate tumorigenic activities and the emergence of therapy-resistant phenotypes. Tumor-associated immune functions are influenced by distinct or overlapping sets of therapeutic modalities, such as cytotoxic chemotherapy, radiotherapy, or molecular-targeted therapy, and various anticancer modalities have unique properties to influence the mode of cross-talk between tumor cells and immune cells in tumor microenvironments. Thus, it is critical to understand precise molecular machineries whereby each anticancer strategy has a distinct or overlapping role in regulating the dynamism of reciprocal communication between tumor and immune cells in tumor microenvironments. Such an understanding will open new therapeutic opportunities by harnessing the immune system to overcome resistance to conventional anticancer drugs.