Family-genetic studies of psychiatric disorders. Developing technologies.
Family-genetic studies of psychiatric disorders. Developing technologies.
复制标题
DOI：
10.1001/archpsyc.1986.01800110090012
复制
发表时间：
1986-11
影响因子：
--
通讯作者：
M. Weissman;K. Merikangas;K. John;P. Wickramaratne;B. Prusoff;K. Kidd
中科院分区：
文献类型：
--
作者：
M. Weissman;K. Merikangas;K. John;P. Wickramaratne;B. Prusoff;K. Kidd
在过去的十年中，新的概念和技术已经改善了精神病学中家族遗传学研究的进行。我们对这些进展进行了汇编和批判性评估，包括研究设计、系谱收集、成人和儿童的诊断程序以及流行病学和遗传学方法进行数据分析。这些方法改进了关于家庭中精神病的性质和模式的准确信息的收集。从精心设计和良好进行的家庭研究所产生的数据是有用的，用于识别同质亚组的精神疾病，了解精神疾病的频谱，检查精神疾病之间的关联，并研究成人和儿童之间的精神疾病表现的连续性。这些研究的结果也可能提高我们的能力，以确定精神疾病的传播模式，并选择潜在的信息家庭，为未来的遗传连锁研究，使用新的重组DNA技术。这些方法的适应，以常规的临床实践和新的方向，在家庭遗传学研究的应用，采用更精细的评估和分析方法进行了讨论。
During the past decade new concepts and technologies have improved the conduct of family-genetic studies in psychiatry. We compiled and critically evaluated these advances, including study design, pedigree collection, diagnostic procedures in adults and children, and epidemiologic and genetic approaches to data analysis. These approaches have improved the collection of accurate information on the nature and patterns of psychiatric illness in families. The data generated from well-designed and well-conducted family studies are useful for the identification of homogeneous subgroups of psychiatric disorders, for understanding the spectrum of psychiatric disorders, for examining the associations between psychiatric disorders, and for studying the continuity between adult and childhood manifestations of psychiatric disorders. Findings from these studies also may enhance our capacity to identify the mode of transmission of the psychiatric disorders and to select potentially informative families for future genetic linkage studies using the new recombinant DNA techniques. The adaptation of these methods to routine clinical practice and new directions in the application of family-genetic studies employing more refined assessments and analytic methods are also discussed.