[A review of drug metabolism under hypoxia environment at high altitude].
[A review of drug metabolism under hypoxia environment at high altitude].
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发表时间：
2015-09
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通讯作者：
Juan-ling Zhang;Xiang-yang Li
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作者：
Juan-ling Zhang;Xiang-yang Li
高原特殊的环境特征，如低气压、低温、干旱、高太阳辐射、气候多变和化探异常等，对人类的生理和健康造成了极大的影响。为高原低氧特殊环境下药物代谢的研究提供有价值的参考和新思路，为高原地区临床合理用药、避免不良反应和个体化用药提供指导。本文综述了高原低氧对药物代谢的影响，阐述了一些药物在高原低氧环境下的代谢特点及药物代谢酶的活性和表达，并对相关机制进行了探讨。
The special environmental features of high altitude, such as hypobaric hypoxia, low temperature, arid, high solar radiation, variable climate and geochemical anomaly, cause great effects on human physiology and health. It will provide valuable references and new ideas to study drug's metabolism in special environment of high altitude hypoxia, and give the guidance to clinical reasonable medication, avoiding adverse reactions and personalized medicine in plateau areas. This article reviewed the effect of high altitude hypoxia on drug metabolism, elaborated metabolic characteristics of some drugs and the activity and expression of drug metabolism enzymes under hypoxia environment at high altitude, and discussed related mechanism.