Intratracheal surfactant administration preserves airway compliance during lung reperfusion.
Intratracheal surfactant administration preserves airway compliance during lung reperfusion.
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气管内表面活性剂给药可在肺再灌注期间保持气道顺应性。
DOI：
10.1016/s0003-4975(96)00612-1
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Kron,IL
中科院分区：
文献类型：
--
作者：
Buchanan,SA;Mauney,MC;Parekh,VI;DeLima,NF;Binns,OA;Cope,JT;Shockey,KS;Tribble,CG;Kron,IL
研究背景：严重缺血再灌注损伤患者肺移植后气道顺应性降低。此外，表面活性剂系统在肺保存和再灌注后受损。我们假设同种异体移植物储存后更换表面活性剂可以在再灌注时保持气道顺应性。方法用50 mL/kg冷生理盐水冲洗兔肺。立即对照肺采用孤立通气/灌注仪，使用静脉兔血以40 mL/min的速度循环，室内空气通气20次/min，气道压力恒定（n = 8）。24小时对照肺在4℃保存24小时，然后进行类似的研究（n = 7）。表面活性物质肺同样采集并保存24小时，但在再灌注前5分钟给予1.5 mL/kg气管内表面活性物质（n = 10）。在再灌注30min期间连续记录气道压力和流量。30分钟计算潮气量和气道顺应性。结果即刻对照组、24小时对照组和表面活性剂组的血容量分别为33.67±0.57、15.75±5.72、29.83±1.07 mL（表面活性剂组与24小时对照组比较，p = 0.004）。即刻对照组、24小时对照组和表面活性剂组气道顺应性分别为1.94±0.27、0.70±0.09和1.46±0.10 mL/mm Hg（表面活性剂组与24小时对照组比较，p = 0.002）。结论低温保存24小时后再灌注前给予表面活性剂可保持兔肺再灌注损伤模型的潮气量和气道顺应性。
BackgroundDecreased airway compliance after lung transplantation has been observed with severe ischemia-reperfusion injury. Further, it has been shown that the surfactant system is impaired after lung preservation and reperfusion. We hypothesized that surfactant replacement after allograft storage could preserve airway compliance during reperfusion.MethodsRabbit lungs were harvested after flush with 50 mL/kg of cold saline solution. Immediate control lungs were studied with an isolated ventilation/perfusion apparatus using venous rabbit blood recirculated at 40 mL/min, room-air ventilation at 20 breaths/min, and constant airway pressure (n = 8). Twenty-four-hour control lungs were preserved at 4°C for 24 hours and then similarly studied (n = 7). Surfactant lungs underwent similar harvest and preservation for 24 hours, but received 1.5 mL/kg of intratracheal surfactant 5 minutes before reperfusion (n = 10). Airway pressure and flow were recorded continuously during 30 minutes of reperfusion. Tidal volume and airway compliance were calculated at 30 minutes.ResultsTidal volume was 33.67 ± 0.57, 15.75 ± 5.72, and 29.83 ± 1.07 mL in the immediate control, 24-hour control, and surfactant groups, respectively (p = 0.004, surfactant versus 24-hour control). Airway compliance was 1.94 ± 0.27, 0.70 ± 0.09, and 1.46 ± 0.10 mL/mm Hg in the immediate control, 24-hour control, and surfactant groups, respectively (p = 0.002, surfactant versus 24-hour control).ConclusionsWe conclude that surfactant administration before reperfusion after 24 hours of cold storage preserves tidal volume and airway compliance in the isolated ventilated/perfused rabbit model of lung reperfusion injury.
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表面活性剂的其他用途。
DOI：
--
发表时间：
1993
期刊：
Clinics of Perinatology
影响因子：
--
作者：
D. Brown;E. Pattishall
通讯作者：
E. Pattishall
外源性表面活性剂治疗在三十八小时肺移植保存中的移植。
影响因子：
6
作者：
R. Novick;R. Veldhuizen;F. Possmayer;John A. Lee;D. Sandler;James F. Lewis
通讯作者：
James F. Lewis
PGE1 和温度对保存后肺功能的影响
影响因子：
6.2
作者：
T. Ueno;H. Yokomise;T. Oka;J. Puskas;E. Mayer;Arthur S Slutsky;G. Patterson
通讯作者：
G. Patterson
通过免疫抑制治疗保留犬肺同种异体移植物中肺表面活性剂的活性。
影响因子：
6
作者：
P. Thomas;P. C. Jolly
通讯作者：
P. C. Jolly
肺表面活性剂混合物抗氧化活性的表征。
DOI：
10.1016/0304-4165(90)90105-6
发表时间：
1990
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Matalon,S;Holm,BA;Baker,RR;Whitfield,MK;Freeman,BA
通讯作者：
Freeman,BA