Hypoglycemic triterpenoid glycosides from Cyclocarya paliurus (Sweet Tea Tree)
Hypoglycemic triterpenoid glycosides from Cyclocarya paliurus (Sweet Tea Tree)
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DOI：
10.1016/j.bioorg.2019.103493
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发表时间：
2020-01-01
影响因子：
5.1
通讯作者：
Xu, Kangping
中科院分区：
文献类型：
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作者：
Sun, Huihui;Tan, Jie;Xu, Kangping
从青钱柳(Juglandaceae)植物青钱柳叶的70%乙醇提取物中分离得到4个新化合物，其中1-4为新化合物，5-8为新化合物，9-12为已知化合物。通过1D/2D核磁共振和HRESIMS数据，结合化学分析和DFT Giao C-13核磁共振计算，确定了它们的结构。在生物活性测定中，化合物5-8显著增加了3T3-L1脂肪细胞的葡萄糖消耗，这可能是青钱柳传统用途抗糖尿病作用的生物活性成分。
Four new rarely occurred seco-dammarane triterpenoid glycosides (1-4) and four new dammarane triterpenoid glycosides (5-8), along with four known triterpenoids (9-12), were isolated from the 70% ethanol extract of the leaves of Cyclocarya paliurus (family Juglandaceae). Their structures were elucidated by extensive spectroscopic methods, including 1D/2D NMR and HRESIMS data, together with chemical analysis and DFT GIAO C-13 NMR calculation. In bioassay, compounds 5-8 significantly increased glucose consumption in 3T3-L1 adipocytes, which could be the bioactive constituents for the anti-diabetes effect of the traditional usage of C. paliurus.