Protection against fine particle-induced pulmonary and systemic inflammation by omega-3 polyunsaturated fatty acids
Protection against fine particle-induced pulmonary and systemic inflammation by omega-3 polyunsaturated fatty acids
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DOI：
10.1016/j.bbagen.2016.12.018
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发表时间：
2017-03-01
影响因子：
3
通讯作者：
Kang, Jing X.
中科院分区：
文献类型：
--
作者：
Li, Xiang-Yong;Hao, Lei;Kang, Jing X.
背景：暴露于细颗粒物，例如通过空气污染，与慢性病发病率增加有关。然而，几乎没有采取措施来减少与细颗粒物暴露相关的健康风险。鉴定安全有效的方法，以防止细颗粒物吸入相关的damage.Methods：我们使用合成的，无毒的，荧光细颗粒物，调查吸入细颗粒物的物理分布及其对肺部和全身炎症的影响，在小鼠。通过膳食补充剂或fat-1转基因小鼠模型，欧米茄3脂肪酸的组织水平升高。肺和全身炎症的标志物进行了assessed.Results：我们发现，细颗粒物不仅积累在肺部，但也可以穿透肺屏障，并进入其他器官，包括脑，肝，脾，肾和睾丸。这些颗粒诱导肺部和全身炎症，并增加氧化应激。我们还表明，无论是作为一种预防方法，（暴露前）或作为干预措施结论：这些结果推进了我们对细颗粒如何促进疾病发展的理解，并表明增加组织ω-3水平可能是一个有前途的营养手段，以减少风险的疾病引起的颗粒暴露。一般意义：我们的研究结果表明，提高组织欧米茄-3水平可以预防和治疗细颗粒引起的健康问题，从而立即，减少空气污染带来的疾病负担的切实可行的解决方案。(C)2016年6月，作者。由爱思唯尔公司出版
Background: Exposure to fine particulate matter, such as through air pollution, has been linked to the increased incidence of chronic diseases. However, few measures have been taken to reduce the health risks associated with fine particle exposure. The identification of safe and effective methods to protect against fine particle exposure-related damage is urgently needed.Methods: We used synthetic, non-toxic, fluorescent fine particles to investigate the physical distribution of inhaled fine particles and their effects on pulmonary and systemic inflammation in mice. Tissue levels of omega 3 fatty acids were elevated via dietary supplementation or the fat-1 transgenic mouse model. Markers of pulmonary and systemic inflammation were assessed.Results: We discovered that fine particulate matter not only accumulates in the lungs but can also penetrate the pulmonary barrier and travel into other organs, including the brain, liver, spleen, kidney, and testis. These particles induced both pulmonary and systemic inflammation and increased oxidative stress. We also show that elevating tissue levels of omega-3 fatty acids was effective in reducing fine particle-induced inflammation, whether as a preventive method (prior to exposure) or as an intervention (after exposure).Conclusions: These results advance our understanding of how fine particles contribute to disease development and suggest that increasing tissue omega-3 levels may be a promising nutritional means for reducing the risk of diseases induced by particle exposure.General significance: Our findings demonstrate that elevating tissue omega-3 levels can prevent and treat fine particle-induced health problems and thereby present an immediate, practical solution for reducing the disease burden of air pollution. (C) 2016 The Authors. Published by Elsevier B.V.