Subgroups of parvalbumin-expressing interneurons in layers 2/3 of the visual cortex
Subgroups of parvalbumin-expressing interneurons in layers 2/3 of the visual cortex
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DOI：
10.1152/jn.00782.2012
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发表时间：
2013-03-01
影响因子：
2.5
通讯作者：
Wollmuth, Lonnie P.
中科院分区：
文献类型：
--
作者：
Helm, Jessica;Akgul, Gulcan;Wollmuth, Lonnie P.
首页--期刊主要分类--期刊细介绍--期刊题录与文摘--文摘内容视皮层第2/3层中表达小白蛋白的中间神经元亚群。神经生理学杂志109：1600-1613,2013。2012年12月28日首次出版；doi：10.1152/jn.00782.2012。-抑制性中间神经元的输入、处理和输出特性有助于塑造通过视觉皮质第2/3层的信息流。小白蛋白(PV)阳性中间神经元调节和同步锥体神经元的增益和动态反应。为了确定发育中的视皮层第2/3层PV中间神经元的多样性，我们对它们的被动和主动膜特性进行了表征。利用Ward‘s和k-均值多维聚类，我们识别了四个PV中间神经元亚群。两个亚组之间最显著的不同是他们对略高于血流底的中等刺激反应的放电模式。两个亚组在所有刺激强度的基础上表现出规则和连续的放电。这两个连续激发的亚群之间的不同之处在于，其中一个亚群的激发频率要高得多，并在基频或接近基频时过渡到这个高频激发频率。另外两个亚组显示出不规则的、口吃的放电模式，恰好在血流底之上。这两个亚组通常都会在强烈刺激下转变为规则和持续的放电，但其中一个亚组，即强口吃亚组，在更广泛的刺激强度和放电频率范围内表现出不规则的放电。这四个亚组在兴奋性突触输入上也存在差异，为亚组的分类提供了独立的支持。这里确定的PV中间神经元亚群对不同强度和频率的输入会做出不同的反应，在发育中的神经回路中产生不同的PV抑制模式。
Helm J, Akgul G, Wollmuth LP. Subgroups of parvalbumin-expressing interneurons in layers 2/3 of the visual cortex. J Neurophysiol 109: 1600-1613, 2013. First published December 28, 2012; doi: 10.1152/jn.00782.2012.-The input, processing, and output characteristics of inhibitory interneurons help shape information flow through layers 2/3 of the visual cortex. Parvalbumin (PV)-positive interneurons modulate and synchronize the gain and dynamic responsiveness of pyramidal neurons. To define the diversity of PV interneurons in layers 2/3 of the developing visual cortex, we characterized their passive and active membrane properties. Using Ward's and k-means multidimensional clustering, we identified four PV interneuron subgroups. The most notable difference between the subgroups was their firing patterns in response to moderate stimuli just above rheobase. Two subgroups showed regular and continuous firing at all stimulus intensities above rheobase. The difference between these two continuously firing subgroups was that one fired at much higher frequencies and transitioned into this high-frequency firing rate at or near rheobase. The two other subgroups showed irregular, stuttering firing patterns just above rheobase. Both of these subgroups typically transitioned to regular and continuous firing at intense stimulations, but one of these subgroups, the strongly stuttering subgroup, showed irregular firing across a wider range of stimulus intensities and firing frequencies. The four subgroups also differed in excitatory synaptic input, providing independent support for the classification of sub-groups. The subgroups of PV interneurons identified here would respond differently to inputs of varying intensity and frequency, generating diverse patterns of PV inhibition in the developing neural circuit.