Acupuncture accelerates wound healing in burn-injured mice
Acupuncture accelerates wound healing in burn-injured mice
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DOI：
10.1016/j.burns.2010.07.005
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发表时间：
2011-02-01
期刊：
影响因子：
2.7
通讯作者：
Hong, Seung-Ug
中科院分区：
文献类型：
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作者：
Lee, Jin-Ah;Jeong, Ha Jin;Hong, Seung-Ug
本文比较了针刺对小鼠深二度烧伤创面愈合的影响，并与传统的水胶敷料进行了比较。烧伤后7d，针刺治疗后创面皮肤炎症蛋白-1α(MIP-1α)的表达水平明显降低，血中嗜酸性粒细胞数量明显减少。此外，针刺治疗在缩小创面面积和诱导表皮再生方面效果更好。组织学结果还显示，针灸治疗的创面中白细胞浸润较少，对MIP-2的免疫组织化学反应较多。此外，针刺治疗7d后BrdU和碱性成纤维细胞生长因子(BFGF)阳性细胞数明显高于双皮针治疗组。此外，在针刺治疗的小鼠中，7d时纤维连接蛋白的表达增加，α-SMA表达减少。因此，本研究表明，针刺可加速深二度烧伤后皮肤再生过程。(C)2010年爱思唯尔有限公司和ISBI。版权所有。
The effects of acupuncture on healing of deep second degree burns were compared to the conventional hydrocolloid dressing, Duoderm in mice. The expression level of inflammatory protein-1 alpha (MIP-1 alpha) was significantly reduced in the injured skin and the number of eosinophils in blood decreased significantly following the acupuncture treatment compared to the Duoderm dressing at 7 days after the burn. In addition, the acupuncture treatment was more effective in decreasing the wound size and inducing epidermal regeneration. Histological findings also revealed that there was less leukocyte infiltration and a greater reduction in the immunohistochemical reaction to MIP-2 in the wounds treated with acupuncture versus Duoderm. Furthermore, the numbers of BrdU- and basic fibroblast growth factor (bFGF)-positive cells were significantly increased by the acupuncture treatment, compared to the Duoderm treatment at 7 days. Moreover, in the acupuncture treated mice, the expression of fibronectin was increased and alpha-SMA was decreased at 7 days. Thus, this present study demonstrates that acupuncture accelerates the skin regeneration process following deep second degree burns. (c) 2010 Elsevier Ltd and ISBI. All rights reserved.