Two-dimensional quantitative photoacoustic image reconstruction of absorption distributions in scattering media by use of a simple iterative method
Two-dimensional quantitative photoacoustic image reconstruction of absorption distributions in scattering media by use of a simple iterative method
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DOI：
10.1364/ao.45.001866
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发表时间：
2006-03-10
期刊：
影响因子：
1.9
通讯作者：
Beard, PC
中科院分区：
文献类型：
--
作者：
Cox, BT;Arridge, SR;Beard, PC
光声成像是一种用于显示软组织内部结构和功能的非侵入性生物医学成像手段。通常，根据光诱导的声发射的测量重建与所吸收的光能量成正比的图像。我们描述了一种简单的迭代算法，从吸收的光能量的图像中恢复光吸收系数的分布。该算法结合了基于扩散的光传输有限元模型，快速收敛到绝对吸收系数分布的准确估计上。给出了具有生理上逼真的光学性质的二维例子。恢复光学性质(直接反映组织生理学)的能力可以加强光声成像技术，特别是基于生色团光谱分析的方法。(C)2006年美国光学学会。
Photoacoustic imaging is a noninvasive biomedical imaging modality for visualizing the internal structure and function of soft tissues. Conventionally, an image proportional to the absorbed optical energy is reconstructed from measurements of light-induced acoustic emissions. We describe a simple iterative algorithm to recover the distribution of optical absorption coefficients from the image of the absorbed optical energy. The algorithm, which incorporates a diffusion-based finite-element model of light transport, converges quickly onto an accurate estimate of the distribution of absolute absorption coefficients. Two-dimensional examples with physiologically realistic optical properties are shown. The ability to recover optical properties (which directly reflect tissue physiology) could enhance photoacoustic imaging techniques, particularly methods based on spectroscopic analysis of chromophores. (c) 2006 Optical Society of America.