Cancer Risk in a Large Inception Systemic Lupus Erythematosus Cohort: Effects of Demographic Characteristics, Smoking, and Medications.
Cancer Risk in a Large Inception Systemic Lupus Erythematosus Cohort: Effects of Demographic Characteristics, Smoking, and Medications.
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DOI：
10.1002/acr.24425
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发表时间：
2021-12
影响因子：
4.7
通讯作者：
Clarke AE
中科院分区：
文献类型：
--
作者：
Bernatsky S;Ramsey-Goldman R;Urowitz MB;Hanly JG;Gordon C;Petri MA;Ginzler EM;Wallace DJ;Bae SC;Romero-Diaz J;Dooley MA;Peschken CA;Isenberg DA;Rahman A;Manzi S;Jacobsen S;Lim SS;van Vollenhoven R;Nived O;Kamen DL;Aranow C;Ruiz-Irastorza G;Sánchez-Guerrero J;Gladman DD;Fortin PR;Alarcón GS;Merrill JT;Kalunian KC;Ramos-Casals M;Steinsson K;Zoma A;Askanase A;Khamashta MA;Bruce I;Inanc M;Clarke AE
To assess cancer risk factors in incident SLE. Clinical variables and cancer outcomes were assessed annually among incident SLE patients. Multivariate hazard regression models (over-all risk, and most common cancers) included demographics and time-dependent medications (corticosteroids, antimalarial drugs, immunosuppressants), smoking, and adjusted mean SLE Disease Activity Index-2K. Among 1668 patients (average 9 years follow-up), 65 cancers occurred: 15 breast, 10 non-melanoma skin, seven lung, six hematological, six prostate, five melanoma, three cervical, three renal, two each gastric, head and neck, and thyroid, and one each rectal, sarcoma, thymoma, and uterine cancers. Half of cancers (including all lung cancers) occurred in past/current smokers, versus one-third of patients without cancer. Multivariate analyses indicated over-all cancer risk was related primarily to male sex and older age at SLE diagnosis. In addition, smoking was associated with lung cancer. For breast cancer risk, age was positively and anti-malarial drugs were negatively associated. Anti-malarial drugs and higher disease activity were also negatively associated with non-melanoma skin cancer (NMSC) risk, whereas age and cyclophosphamide were positively associated. Disease activity was associated positively with hematologic and negatively with NMSC risk. Smoking is a key modifiable risk factor, especially for lung cancer, in SLE. Immunosuppressive medications were not clearly associated with higher risk except for cyclophosphamide and NMSC. Antimalarials were negatively associated with breast cancer and NMSC risk. SLE activity was associated positively with hematologic cancer and negatively with NMSC. Since the absolute number of cancers was small, additional follow-up will help consolidate these findings.
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影响因子：
27.4
作者：
Bernatsky, S.;Joseph, L.;Clarke, A. E.
通讯作者：
Clarke, A. E.
DOI：
10.1158/1078-0432.ccr-13-3227
发表时间：
2014-06-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Cook KL;Wärri A;Soto-Pantoja DR;Clarke PA;Cruz MI;Zwart A;Clarke R
通讯作者：
Clarke R
影响因子：
--
作者：
Dreyer, Lene;Faurschou, Mikkel;Jacobsen, Soren
通讯作者：
Jacobsen, Soren
DOI：
10.1097/jto.0b013e318262de4a
发表时间：
2012-10
期刊：
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
影响因子：
--
作者：
Goldberg SB;Supko JG;Neal JW;Muzikansky A;Digumarthy S;Fidias P;Temel JS;Heist RS;Shaw AT;McCarthy PO;Lynch TJ;Sharma S;Settleman JE;Sequist LV
通讯作者：
Sequist LV
羟氯喹通过增强化疗敏化和促进 M2-TAM 向 M1 样巨噬细胞的转变来诱导肺癌抑制。
DOI：
10.1186/s13046-018-0938-5
发表时间：
2018-10-29
期刊：
Journal of experimental & clinical cancer research : CR
影响因子：
--
作者：
Li Y;Cao F;Li M;Li P;Yu Y;Xiang L;Xu T;Lei J;Tai YY;Zhu J;Yang B;Jiang Y;Zhang X;Duo L;Chen P;Yu X
通讯作者：
Yu X